中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
12期
2127-2130,2131
,共5页
中草药%孕烷X受体%组成型雄烷受体%药物相互作用
中草藥%孕烷X受體%組成型雄烷受體%藥物相互作用
중초약%잉완X수체%조성형웅완수체%약물상호작용
Chinese herbal medicines%PXR%CAR%Drug interactions
孕烷X受体( pregnane X receptor, PXR)是核受体亚家族的成员之一,参与大量的外源性和内源性化学物质的生物转化,能被多种中草药激活,调节下游靶基因的表达,在药物代谢酶和转运体的调节中起重要作用。组成型雄烷受体(constitutive androstane receptor,CAR)和PXR一样能与外源性配体结合调节CYP2B6、CYP3A4、CYP2C19、UGT1A1的表达,共同参与CYP药物代谢酶的调节,成为药物作用的靶标。
孕烷X受體( pregnane X receptor, PXR)是覈受體亞傢族的成員之一,參與大量的外源性和內源性化學物質的生物轉化,能被多種中草藥激活,調節下遊靶基因的錶達,在藥物代謝酶和轉運體的調節中起重要作用。組成型雄烷受體(constitutive androstane receptor,CAR)和PXR一樣能與外源性配體結閤調節CYP2B6、CYP3A4、CYP2C19、UGT1A1的錶達,共同參與CYP藥物代謝酶的調節,成為藥物作用的靶標。
잉완X수체( pregnane X receptor, PXR)시핵수체아가족적성원지일,삼여대량적외원성화내원성화학물질적생물전화,능피다충중초약격활,조절하유파기인적표체,재약물대사매화전운체적조절중기중요작용。조성형웅완수체(constitutive androstane receptor,CAR)화PXR일양능여외원성배체결합조절CYP2B6、CYP3A4、CYP2C19、UGT1A1적표체,공동삼여CYP약물대사매적조절,성위약물작용적파표。
Pregnane X receptor ( PXR) , a member of the nuclear receptor subfamily, plays an important role in the regulation of drug metabolic enzymes and transporters. PXR can regulate the expression of downstream target genes through transforming a large number of exogenous and endogenous chemical substances, and can be activated by a variety of Chinese herbal medicines. The same as PXR, constitutive androstane receptor ( CAR) can participate in the regulation of drug metabolic enzyme CYP450 and become the targets of drug action through combining with exogenous ligands to regulate the expression of CYP2B6, CYP3A4, CYP2C19 and UGT1A1.
