CAJ | 학술논문

目的：：探讨重组人干扰素α-2b凝胶联合外用溃疡散治疗合并人乳头瘤病毒(HPV)感染宫颈炎疗效。方法：76例HPV感染宫颈炎患者随机分为观察组36例和对照组40例。观察组给予重组人干扰素α-2b凝胶联合外用溃疡散；对照组仅给予外用溃疡散治疗。连续用药6个月后，比较两组患者HPV转阴情况，评定两组患者疗效，记录两组药品不良反应发生情况。结果：治疗后，观察组 HPV 转阴率83.33%，高于对照组的60.00%(P <0.001)。观察组总有效率88.89%，高于对照组的82.50%(P <0.05)。两组的不良反应发生情况差异无统计学意义。结论：重组人干扰素α-2b凝胶联合外用溃疡散对HPV感染宫颈炎临床疗效显著，值得临床推广应用。
목적：：탐토중조인간우소α-2b응효연합외용궤양산치료합병인유두류병독(HPV)감염궁경염료효。방법：76례HPV감염궁경염환자수궤분위관찰조36례화대조조40례。관찰조급여중조인간우소α-2b응효연합외용궤양산；대조조부급여외용궤양산치료。련속용약6개월후，비교량조환자HPV전음정황，평정량조환자료효，기록량조약품불량반응발생정황。결과：치료후，관찰조 HPV 전음솔83.33%，고우대조조적60.00%(P <0.001)。관찰조총유효솔88.89%，고우대조조적82.50%(P <0.05)。량조적불량반응발생정황차이무통계학의의。결론：중조인간우소α-2b응효연합외용궤양산대HPV감염궁경염림상료효현저，치득림상추엄응용。
Objective:To investigate the clinical efficacy of recombinant human interferon α-2b gels combined with ulcer powders for external use in the treatment of cervicitis patients with human papillomavirus infection. Methods: Totally 76 cases of cervicitis patients with human papillomavirus infection were randomly divided into the observation group and the control group. The observation group was treated by recombinant human interferonα-2b gels combined with ulcer powders for external use through vaginal administration, once every 2d on bedtime. The control group was treated only by ulcer powders for external use. After the 6-month treatment, the HPV negative conversion rate, clinical efficacy and adverse drug reactions in the two groups were detected. Results:After the treatment, the HPV negative conversion rate of the observation group was 83. 33%, which was higher than that of the control group (60. 00%, P <0. 001). The total effective rate of the observation group was 88. 89%, which was higher than that of the control group (82. 50%, P < 0. 05). Conclusion: The clinical efficacy of recombinant human interferon α-2b gels combined with ulcer powders for external use in the treatment of cervicitis patients with human papillomavirus infection is significant, which is worthy of wider application.