CAJ | 학술논문

目的：改进免疫抑制剂芬戈莫德的合成工艺。方法以2-苯乙醇和溴化钠为起始原料，经取代、酰化、缩合等反应制得芬戈莫德。结果目标化合物的结构经1 H-NMR谱和MS确证。总收率为26.9％，比文献收率提高了6.4％。结论改进后的工艺路线方法操作简便、反应条件温和、收率高、成本低，有利于工业化生产。
목적：개진면역억제제분과막덕적합성공예。방법이2-분을순화추화납위기시원료，경취대、선화、축합등반응제득분과막덕。결과목표화합물적결구경1 H-NMR보화MS학증。총수솔위26.9％，비문헌수솔제고료6.4％。결론개진후적공예로선방법조작간편、반응조건온화、수솔고、성본저，유리우공업화생산。
Objective To synthesize fingolimod. Methods Fingolimod was synthesized with 2-phenethyl alcohol and sodium bromide as starting material,and through a series of reactions,such as substitution,acylation,condensation etc. Results The struture of target compound was confirmed by 1 H-NMR and MS. The overall yield of the process was 26. 9 % . Compared with the reported method,the overall yield was 6. 4% higher. Conclusion This synthetic process was convenient,and had high yield,low cost,and mild reaction condition. It was suitable for industrial production by its opera-tion,low cost and.