CAJ | 학술논문

目的：观察感染日本血吸虫不同时间动物内脏中沉积虫卵的分布特征及组织病理变化。方法新西兰大白兔定量人工感染血吸虫后，比较感染后42、60 d沉积虫卵在组织中的分布特征、虫卵孵化率的变化以及相应部位的病理改变。结果感染42 d时，沉积虫卵百分比、每克组织沉积虫卵数及沉积虫卵孵化率最高的均为肝脏；感染60 d时，上述3个指标值最高的分别为肝脏、直肠和小肠上段。从感染后42 d到60 d，兔肝脏肿大，且由黑色逐渐变成暗灰色并失去弹性而硬化，小肠各段逐渐出现虫卵结节，结肠、盲肠和直肠可见黏膜充血、水肿、结节，病变程度与虫卵的沉积相关。结论新西兰大白兔感染日本血吸虫后不同时期，不同器官组织的沉积虫卵数量、密度及虫卵孵化率均有差异，且沉积虫卵的分布和宿主病理损伤程度有关。
목적：관찰감염일본혈흡충불동시간동물내장중침적충란적분포특정급조직병리변화。방법신서란대백토정량인공감염혈흡충후，비교감염후42、60 d침적충란재조직중적분포특정、충란부화솔적변화이급상응부위적병리개변。결과감염42 d시，침적충란백분비、매극조직침적충란수급침적충란부화솔최고적균위간장；감염60 d시，상술3개지표치최고적분별위간장、직장화소장상단。종감염후42 d도60 d，토간장종대，차유흑색축점변성암회색병실거탄성이경화，소장각단축점출현충란결절，결장、맹장화직장가견점막충혈、수종、결절，병변정도여충란적침적상관。결론신서란대백토감염일본혈흡충후불동시기，불동기관조직적침적충란수량、밀도급충란부화솔균유차이，차침적충란적분포화숙주병리손상정도유관。
Objective To study the distribution characteristics of deposited eggs and pathological changes in the viscera of animal infected with Schistosoma japonicum at different time. Methods New Zealand white rabbits were infected artificially with quantitative S. japonicum miracidia,then the distribution characteristics and the hatchability of schistosome eggs as well as the pathological changes of the corresponding viscera of the rabbits 42 and 60 d post?infection were observed and compared. Re?sults On the 42nd day post?infection,among all the viscera observed,the percentage of eggs deposited,the number of eggs per gram and the hatchability were the highest in the liver,while on the 60th day post?infection,the tissues and organs with the highest values of the above 3 indexes were the liver,rectum and upper section of the small intestine,respectively. From 42 day to 60 day post?infection,the liver of infected rabbits became swelling,hardening and lost elasticity,the color changed from black to dark grey,and egg nodules gradually appeared in the different sections of the small intestine,and also the mucosal hy?peremia,edema and egg nodules were seen in the colon,cecum and rectum. The lesion levels tended to be correlated with the deposition of eggs. Conclusion The amount and the density as well as the hatching rate of deposited eggs of S. japonicum in the viscera of infected rabbits at different time are different,and the lesion level in the host is correlated with the deposition of eggs.