CAJ | 학술논문

目的：：确定NB－UVB照射对白癜风局部皮损组织液细胞因子IL－6、IL－18、TNF－α以及sl￣CAM－1水平的影响。方法： NB－UVB照射白癜风皮损区30次,采用ELISA法检测白癜风患者NB－UVB照射前后局部皮损组织液中IL－6、IL－18、TNF－α以及slCAM－1水平。结果：皮损区组织液中IL－6为0.316±0.237 ng/mL,低于健康人群,IL－18为0.925±0.419 ng/mL、TNF－α为1.012±0.473 ng/mL、slCAM－1为1.162±0.386 ng/mL,均高于健康人群。经NB－UVB照射后,复色区各细胞因子水平基本恢复正常。结论： NB－UVB可能通过对细胞因子的调节起到治疗白癜风的作用。
목적：：학정NB－UVB조사대백전풍국부피손조직액세포인자IL－6、IL－18、TNF－α이급sl￣CAM－1수평적영향。방법： NB－UVB조사백전풍피손구30차,채용ELISA법검측백전풍환자NB－UVB조사전후국부피손조직액중IL－6、IL－18、TNF－α이급slCAM－1수평。결과：피손구조직액중IL－6위0.316±0.237 ng/mL,저우건강인군,IL－18위0.925±0.419 ng/mL、TNF－α위1.012±0.473 ng/mL、slCAM－1위1.162±0.386 ng/mL,균고우건강인군。경NB－UVB조사후,복색구각세포인자수평기본회복정상。결론： NB－UVB가능통과대세포인자적조절기도치료백전풍적작용。
Objective:To determine the effects of NB-UVB on the levels of IL-6, IL-18, TNF-αand sl￣CAM-1 in the lesions of vitiligo. Methods:The lesional levels of IL-6, IL-18, TNF-αand slCAM-1 were detected by ELISA before and after irradiation by NB-UVB for 30 times. Results:Before the irradiation of NB-UVB, the level of IL-6 was 0.316±0.237 ng/mL, which was lower than that in healthy people;the levels of IL-18, TNF-α, slCAM-1 were 0.925±0.419 ng/mL, 1.012±0.473 ng/mL and 1.162±0.386 ng/mL, which were higher than those of the healthy people. After the irradiation of NB-UVB,all the cytokine levels in the improved lesions were basically restored to normal. Conclusion:The efficacy of NB-UVB on vitiligo may be through regulating the levels of cytokines.