CAJ | 학술논문

小儿急性化脓性扁桃体炎和急性细菌性鼻窦炎的细菌学特点多中心研究
소인급성화농성편도체염화급성세균성비두염적세균학특점다중심연구
Multicenter study on the bacteriology characteristic of acute suppurative tonsillitis and acute bacterial sinusitis in children

万方数据

发育医学电子杂志髮育醫學電子雜誌 발육의학전자잡지
Journal of Developmental Medicine (Electronic Version)
2014年 4期 198-203 ,共6页

张国成%刘世喜%成焕吉%邓育林%李云%鲍一笑%谢娟娟%赵琳%周薇%王德辉%王家东%张芩娜%陈继川%何刚%肖旭平

장국성%류세희%성환길%산육림%리운%포일소%사연연%조림%주미%왕덕휘%왕가동%장금나%진계천%하강%초욱평

急性化脓性扁桃体炎%急性细菌性鼻窦炎%细菌学%多中心研究急性化膿性扁桃體炎%急性細菌性鼻竇炎%細菌學%多中心研究
급성화농성편도체염%급성세균성비두염%세균학%다중심연구
Acute suppurative tonsillitis%Acute bacterial sinusitis%Bacteriology%Multicenter study

目的探讨小儿急性化脓性扁桃体炎和急性细菌性鼻窦炎的细菌学特点，观察常用抗生素对分离的5种主要致病菌的敏感性。方法在14家研究机构分别用咽拭子采取急性化脓性扁桃体炎患儿扁桃体表面分泌物和在鼻内镜下对急性细菌性鼻窦炎用拭子采样中鼻道分泌物标本，并进行细菌培养、种属鉴定和常用抗生素最低抑菌浓度（MIC）测定。结果共计入组研究273例中，142例(53.2%)至少分离出一种菌株感染，其中扁桃体炎组136例中(47.1%)至少分离出一种菌株，主要为金黄色葡萄球菌、肺炎链球菌；鼻窦炎152例中78例(56.9%)至少有一种菌株感染，主要为流感嗜血杆菌、肺炎链球菌、卡他莫拉菌。在所有测定药物中（头孢妥仑、头孢克洛、头孢克肟、头孢地尼、头孢曲松、阿莫西林/克拉维酸、阿奇霉素、青霉素、苯唑西林和氨苄西林），头孢妥仑对5种主要致病菌的90%抑菌浓度（MIC90）和50%抑菌浓度（MIC50）均处于最低或次低水平，尤其是对肺炎链球菌。结论小儿急性化脓性扁桃体炎和急性细菌性鼻窦炎的细菌学特点不同。头孢妥仑匹酯对分离的5种主要致病菌最敏感。
목적탐토소인급성화농성편도체염화급성세균성비두염적세균학특점，관찰상용항생소대분리적5충주요치병균적민감성。방법재14가연구궤구분별용인식자채취급성화농성편도체염환인편도체표면분비물화재비내경하대급성세균성비두염용식자채양중비도분비물표본，병진행세균배양、충속감정화상용항생소최저억균농도（MIC）측정。결과공계입조연구273례중，142례(53.2%)지소분리출일충균주감염，기중편도체염조136례중(47.1%)지소분리출일충균주，주요위금황색포도구균、폐염련구균；비두염152례중78례(56.9%)지소유일충균주감염，주요위류감기혈간균、폐염련구균、잡타막랍균。재소유측정약물중（두포타륜、두포극락、두포극우、두포지니、두포곡송、아막서림/극랍유산、아기매소、청매소、분서서림화안변서림），두포타륜대5충주요치병균적90%억균농도（MIC90）화50%억균농도（MIC50）균처우최저혹차저수평，우기시대폐염련구균。결론소인급성화농성편도체염화급성세균성비두염적세균학특점불동。두포타륜필지대분리적5충주요치병균최민감。
ObjectiveTo investigate the bacteriology characteristics of acute suppurative tonsillitis and acute bacterial sinusitis in children.Method In 14 institutions pharyngeal and nasal swab- based samples of secretions in children with acute suppurative tonsillitis for acute bacterial were obtained and bacteria culture, species identification and the commonly-used MIC determination for antibiotics were conducted.Result A total of 273 cases of children were recruited in the study. 142 cases (53.2%) were isolated at least one bacteria strain. 136 tonsillitis group staphylococcus aureus and streptococcus pneumoniae were predominant. 152 patients with sinusitis, haemophilus influenzae and streptococcus pneumoniae were predominant bacteria. In the determination of all drugs, MIC90 and/or MIC50 of cephalosporins shimron for five pathogenic bacteria were at the low level, especially for streptococcus pneumoniae. ConclusionThere are some different characteristics of bacteriology in acute suppurative tonsillitis and acute bacterial sinusitis. Cephalosporins shimron is most effective for the separated 5 pathogenic bacteria.