CAJ | 학술논문

目的：探究IL-2、IL-12及IL-10与梅毒血清固定形成的关系，提高临床疗效。方法采用ELISA法检测本中心180例梅毒血清固定患者IL-2、IL-12及IL-10的浓度，同时以180例梅毒阴转患者和180例健康献血者作为对照，对检测结果进行回顾性分析。结果观察组的IL-2和IL-12明显低于对治愈组和健康组，差异有统计学意义(P＜0.05)；观察组的IL-10明显高于治愈组和健康组，差异有统计学意义(P＜0.05)；治愈组和健康组的IL-2、IL-10及IL-12均无显著性差异(P＞0.05)。结论 TH1/TH2比例失衡可能是梅毒血清固定形成的重要因素。
목적：탐구IL-2、IL-12급IL-10여매독혈청고정형성적관계，제고림상료효。방법채용ELISA법검측본중심180례매독혈청고정환자IL-2、IL-12급IL-10적농도，동시이180례매독음전환자화180례건강헌혈자작위대조，대검측결과진행회고성분석。결과관찰조적IL-2화IL-12명현저우대치유조화건강조，차이유통계학의의(P＜0.05)；관찰조적IL-10명현고우치유조화건강조，차이유통계학의의(P＜0.05)；치유조화건강조적IL-2、IL-10급IL-12균무현저성차이(P＞0.05)。결론 TH1/TH2비례실형가능시매독혈청고정형성적중요인소。
Objective To explore the relationship between serosistance and IL-2, 12, 10 in patients with syphilis. Methods IL-2, 12 and 10 were detected by enzyme-linked immunosorbent assay in 180 syphilis patients with serosistance, 180 cured syphilis patients and 180 healthy controls. The results were analyzed. Results Compared with cured syphilis patients and healthy controls, IL-2 and 12 were significantly lower, while IL-10 was significantly higher in syphilis patients with serosistance (P<0.05). There was no significant difference of IL-2, 12 and 10 between cured syphilis patients and healthy controls (P>0.05). Conclusion The imbalance of TH1/TH2 maybe one of the important reasons for serosistance formation.