实验与检验医学
實驗與檢驗醫學
실험여검험의학
EXPERIMENTAL AND LABORATORY MEDICINE
2014年
6期
674-676
,共3页
糖尿病%肌球蛋白轻锭激酶%空腹C肽
糖尿病%肌毬蛋白輕錠激酶%空腹C肽
당뇨병%기구단백경정격매%공복C태
Diabetes mellitus%Myosin light kinase%Fasting C peptide
目的：探讨糖尿病患者血清非骨骼肌型肌球蛋白轻链激酶(nskMLCK)和常用糖尿病检测指标的关系，以及nskMLCK在糖尿病时的可能作用。方法检测144例糖尿病患者血清nskMLCK、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、维生素D3(VD3)以及空腹血清C肽水平，采用Spearman等级相关分析各指标与血清nskMLCK的相关性；同时分析包括高血压、高血脂等因素对血清nskMLCK的影响。结果与糖尿病相关检测指标进行相关性分析显示，血清nskMLCK水平与BMI、FPG、HbA1c及VD3之间无相关性，与空腹C肽水平呈负相关(r=－0.187)；分析其它可能影响血清nskMLCK水平的因素表明，血清nskMLCK的水平受代谢综合征和病程的影响(P=0.045和0.011)，单独高血压、高血脂、白内障及性别与血清nskMLCK水平无关。结论糖尿病时，患者血清nskMLCK与空腹C肽的负相关提示血清nskMLCK可能参与了胰岛素水平的调节，在糖尿病的发生发展中起到重要的作用。
目的：探討糖尿病患者血清非骨骼肌型肌毬蛋白輕鏈激酶(nskMLCK)和常用糖尿病檢測指標的關繫，以及nskMLCK在糖尿病時的可能作用。方法檢測144例糖尿病患者血清nskMLCK、空腹血糖(FPG)、糖化血紅蛋白(HbA1c)、維生素D3(VD3)以及空腹血清C肽水平，採用Spearman等級相關分析各指標與血清nskMLCK的相關性；同時分析包括高血壓、高血脂等因素對血清nskMLCK的影響。結果與糖尿病相關檢測指標進行相關性分析顯示，血清nskMLCK水平與BMI、FPG、HbA1c及VD3之間無相關性，與空腹C肽水平呈負相關(r=－0.187)；分析其它可能影響血清nskMLCK水平的因素錶明，血清nskMLCK的水平受代謝綜閤徵和病程的影響(P=0.045和0.011)，單獨高血壓、高血脂、白內障及性彆與血清nskMLCK水平無關。結論糖尿病時，患者血清nskMLCK與空腹C肽的負相關提示血清nskMLCK可能參與瞭胰島素水平的調節，在糖尿病的髮生髮展中起到重要的作用。
목적：탐토당뇨병환자혈청비골격기형기구단백경련격매(nskMLCK)화상용당뇨병검측지표적관계，이급nskMLCK재당뇨병시적가능작용。방법검측144례당뇨병환자혈청nskMLCK、공복혈당(FPG)、당화혈홍단백(HbA1c)、유생소D3(VD3)이급공복혈청C태수평，채용Spearman등급상관분석각지표여혈청nskMLCK적상관성；동시분석포괄고혈압、고혈지등인소대혈청nskMLCK적영향。결과여당뇨병상관검측지표진행상관성분석현시，혈청nskMLCK수평여BMI、FPG、HbA1c급VD3지간무상관성，여공복C태수평정부상관(r=－0.187)；분석기타가능영향혈청nskMLCK수평적인소표명，혈청nskMLCK적수평수대사종합정화병정적영향(P=0.045화0.011)，단독고혈압、고혈지、백내장급성별여혈청nskMLCK수평무관。결론당뇨병시，환자혈청nskMLCK여공복C태적부상관제시혈청nskMLCK가능삼여료이도소수평적조절，재당뇨병적발생발전중기도중요적작용。
Objective To investigate the correlation between serum non-skeletal muscle myosin light chain kinase (nskMLCK) and other indicators of diabetes, and the possible role of nskMLCK in diabetes. Methods The levels of serum skMLCK,fasting plasma glucose(FPG), glycohemoglobin(HbA1c), Vitamin D3(VD3), and fasting serum C peptide were detected in 144 patients with diabetes. The relationships between serum nskMLCK and other indicators of diabetes were analyzed by Spearman's rank correla-tion analysis, and the influences of hypertension, hyperlipidemia and other factors on the level of serum nskMLCK were also an-alyzed. Results The results showed that serum nskMLCK had no correlation with BMI, FPG, HbA1c and VD3, but had negative cor-relation with fasting C peptide (r=-0.187). Analysis of other factors acting on the levels of serum nskMLCK showed that metabolic syndrome and disease duration could effect the levels of serum nskMLCK (P=0.045 and 0.011, respectively). Hypertension, hyper-lipidemia, cataract and gender was unrelated to the levels of serum nskMLCK. Conclusion The negative correlation with fasting C peptide indicates that serum nskMLCK might play an important role in diabetes.
