CAJ | 학술논문

目的：探讨酪酸梭菌二联活菌散联合消旋卡多曲在婴幼儿腹泻中的治疗效果。方法将120例腹泻的婴幼儿按随机数字表法分为观察组和对照组，每组60例。对照组给予酪酸梭菌二联活菌散治疗，观察组在对照组治疗的基础上加用消旋卡多曲治疗。对2组患儿疗效、临床症状缓解（大便好转、退热、止泻）时间及治疗前、治疗72 h后症状积分（腹泻、腹痛、腹胀、大便异常）进行比较。结果观察组总有效率为90.0%，对照组总有效率为75.0%，2组比较差异有统计学意义（P＜0.05）。观察组大便好转、退热及止泻时间均短于对照组（均P＜0.05）。2组患儿治疗前症状积分比较差异无统计学意义(P＞0.05)；治疗72 h后2组症状积分均明显低于治疗前、观察组的各项症状积分均明显低于对照组(均P＜0.05)。2组均未见明显的不良反应。结论酪酸梭菌二联活菌散联合消旋卡多曲能提高婴幼儿腹泻的治疗效果，且起效迅速，不良反应少，服用安全。
목적：탐토락산사균이련활균산연합소선잡다곡재영유인복사중적치료효과。방법장120례복사적영유인안수궤수자표법분위관찰조화대조조，매조60례。대조조급여락산사균이련활균산치료，관찰조재대조조치료적기출상가용소선잡다곡치료。대2조환인료효、림상증상완해（대편호전、퇴열、지사）시간급치료전、치료72 h후증상적분（복사、복통、복창、대편이상）진행비교。결과관찰조총유효솔위90.0%，대조조총유효솔위75.0%，2조비교차이유통계학의의（P＜0.05）。관찰조대편호전、퇴열급지사시간균단우대조조（균P＜0.05）。2조환인치료전증상적분비교차이무통계학의의(P＞0.05)；치료72 h후2조증상적분균명현저우치료전、관찰조적각항증상적분균명현저우대조조(균P＜0.05)。2조균미견명현적불량반응。결론락산사균이련활균산연합소선잡다곡능제고영유인복사적치료효과，차기효신속，불량반응소，복용안전。
Objective To investigate the efficacy of Changlekang (combined clostridium butyricum and bifidobacterium powders, live) and racecadotril in the treatment of infantile diarrhea. Methods A total of 120 infants with diarrhea were randomly treated with Combined clostrdium butyricum and bifidobacterium powders,live (control group, n=60) or in combination with racecadotril (observation group, n=60). The efficacy and time to symptom remission (improvement defecation, abatement of fever and cessation of diarrhea) were compared between the two groups. In addition, the symptom scores (diarrhea, abdominal pain, abdominal distension and abnormal defecation) were measured before and after treatment for 72 hours. Results The total effective rate in observation group was significantly higher than that in control group(90.0%vs 75.0%,P<0.05).The time to symptom remission in observation group was significantly shorter than that in control group (P<0.05). There were no obvious differences in symptom scores between the two groups before treatment(P>0.05).After treatment for 72 hours, symptom scores markedly decreased in both groups, and observation group had a significantly lower symptom scores than control group (P<0.05). No obvious adverse reactions were found in both groups. Conclusion Changlekang combined with racecadotril is an effective, fast and safe treatment and leads to fewer adverse effects on infantile diarrhea.