实用临床医学
實用臨床醫學
실용림상의학
Practical Clinical Medicine
2014年
9期
20-21,25
,共3页
钟谷平%范惠珍%盛建文%熊超亮%胥宾芬%吴裕文
鐘穀平%範惠珍%盛建文%熊超亮%胥賓芬%吳裕文
종곡평%범혜진%성건문%웅초량%서빈분%오유문
糖尿病%胰腺癌%早期诊断
糖尿病%胰腺癌%早期診斷
당뇨병%이선암%조기진단
diabetes%pancreatic cancer%early diagnosis
目的：探讨糖尿病相关性胰腺癌的早期诊断。方法选取117例胰腺癌患者（胰腺癌组）、其他癌症患者156例（对照1组）和2型糖尿病患者126例（对照2组），对比各组糖尿病的例数及病程，测定各组患者血清胰淀粉样多肽（IAPP）的含量，分析糖尿病相关性胰腺癌的早期诊断依据。结果胰腺癌组有22例糖尿病（合并糖尿病组），对照1组有3例糖尿病，2组比较差异有统计学意义（P<0.05）；合并糖尿病组糖尿病病程≤2年者高于对照2组[86.3%(19/22)比16.7%(21/126)，P<0.05]；合并糖尿病组、对照1组、对照2组患者血清 IAPP 分别为（21.2±11.4）、（7.3±3.2）和（3.7±2.8）pmol·L－1)，合并糖尿病组与对照1组、对照2组比较，差异均有统计学意义（P<0.05）。结论患者在发现肿瘤占位病灶之前可能已有糖代谢异常，尤其是病程≤2年的2型糖尿病，联合检测患者血清IAPP的含量，有助于胰腺癌的早期诊断。
目的：探討糖尿病相關性胰腺癌的早期診斷。方法選取117例胰腺癌患者（胰腺癌組）、其他癌癥患者156例（對照1組）和2型糖尿病患者126例（對照2組），對比各組糖尿病的例數及病程，測定各組患者血清胰澱粉樣多肽（IAPP）的含量，分析糖尿病相關性胰腺癌的早期診斷依據。結果胰腺癌組有22例糖尿病（閤併糖尿病組），對照1組有3例糖尿病，2組比較差異有統計學意義（P<0.05）；閤併糖尿病組糖尿病病程≤2年者高于對照2組[86.3%(19/22)比16.7%(21/126)，P<0.05]；閤併糖尿病組、對照1組、對照2組患者血清 IAPP 分彆為（21.2±11.4）、（7.3±3.2）和（3.7±2.8）pmol·L－1)，閤併糖尿病組與對照1組、對照2組比較，差異均有統計學意義（P<0.05）。結論患者在髮現腫瘤佔位病竈之前可能已有糖代謝異常，尤其是病程≤2年的2型糖尿病，聯閤檢測患者血清IAPP的含量，有助于胰腺癌的早期診斷。
목적：탐토당뇨병상관성이선암적조기진단。방법선취117례이선암환자（이선암조）、기타암증환자156례（대조1조）화2형당뇨병환자126례（대조2조），대비각조당뇨병적례수급병정，측정각조환자혈청이정분양다태（IAPP）적함량，분석당뇨병상관성이선암적조기진단의거。결과이선암조유22례당뇨병（합병당뇨병조），대조1조유3례당뇨병，2조비교차이유통계학의의（P<0.05）；합병당뇨병조당뇨병병정≤2년자고우대조2조[86.3%(19/22)비16.7%(21/126)，P<0.05]；합병당뇨병조、대조1조、대조2조환자혈청 IAPP 분별위（21.2±11.4）、（7.3±3.2）화（3.7±2.8）pmol·L－1)，합병당뇨병조여대조1조、대조2조비교，차이균유통계학의의（P<0.05）。결론환자재발현종류점위병조지전가능이유당대사이상，우기시병정≤2년적2형당뇨병，연합검측환자혈청IAPP적함량，유조우이선암적조기진단。
Objective To study the early diagnosis of diabetes -related pancreatic cancer. Methods The number of cases of diabetes and the course of disease were recorded and serum levels of islet amyloid polypeptidein (IAPP) were measured in 117 patients with pancreatic cancer (pancreatic cancer group), 156 patients with other cancers:(control 1 group) and 126 patients with type 2 diabetes mellitus (control 2 group). The early diagnostic basis for diabetes-related pancreatic cancer was analyzed. Results The number of cases of diabetes in pancreatic cancer group (22 cases, complicated diabetes group) was significantly higher than that in control 1 group (3 cases) (P<0.05). The percentage of patients with a history of diabetes≤2 years among patients with pancreatic cancer complicated by diabetes (86.3%, 19/22) was significantly higher than that among patients with type 2 diabetes. Serum IAPP levels were (21.2±11.4), (7.3±3.2) and (3.7±2.8) pmol·L-1 in complicated diabetes group, control 1 group and control 2 group, respectively. Compared with control 1 or 2 group, serum IAPP levels significantly increased in complicated diabetes group (P<0.05).Conclusion Abnormal glucose metabo-lism may occur before space occupying lesions are found in patients with pancreatic cancer, especially in pancreatic cancer patients with a history of type 2 diabetes mellitus≤2 years. The detection of serum IAPP levels contributes to the early diagnosis of pancreatic cancer.
