CAJ | 학술논문

目的：探讨肺源性心脏病急性发作期患者血浆内皮素（ET-1）、一氧化氮（NO）水平与动脉血气分析、血液流变学及心肌酶学指标的相关性。方法选择30例肺源性心脏病急性加重期患者为观察组，分别于入院时以及治疗2周后取静脉血对血浆ET-1、NO水平及动脉血气分析、血液流变学、心肌酶谱指标进行检测；另选取30例健康体检者为对照组，对相关指标进行测定。结果观察组治疗前ET-1、NO以及心肌酶谱和血液流变学指标与对照组比较差异均有统计学意义（P<0.05），经2周的系统治疗后，观察组各项指标较治疗前均明显改善，差异有统计学意义（P<0.05）。 Pearson相关性分析结果显示，ET-1和NO水平与动脉血PaO2呈负相关（r=-0.567、-0.583，P<0.05），与动脉血PaCO2、全血黏度和血浆黏度呈正相关（r=0.558、0.602、0.493，0.568、0.587、0.501；P<0.05）。结论血浆ET-1和NO水平可作为肺源性心脏病急性加重期患者病情严重程度及判断预后的重要参考指标。
목적：탐토폐원성심장병급성발작기환자혈장내피소（ET-1）、일양화담（NO）수평여동맥혈기분석、혈액류변학급심기매학지표적상관성。방법선택30례폐원성심장병급성가중기환자위관찰조，분별우입원시이급치료2주후취정맥혈대혈장ET-1、NO수평급동맥혈기분석、혈액류변학、심기매보지표진행검측；령선취30례건강체검자위대조조，대상관지표진행측정。결과관찰조치료전ET-1、NO이급심기매보화혈액류변학지표여대조조비교차이균유통계학의의（P<0.05），경2주적계통치료후，관찰조각항지표교치료전균명현개선，차이유통계학의의（P<0.05）。 Pearson상관성분석결과현시，ET-1화NO수평여동맥혈PaO2정부상관（r=-0.567、-0.583，P<0.05），여동맥혈PaCO2、전혈점도화혈장점도정정상관（r=0.558、0.602、0.493，0.568、0.587、0.501；P<0.05）。결론혈장ET-1화NO수평가작위폐원성심장병급성가중기환자병정엄중정도급판단예후적중요삼고지표。
ABSTRACT:Objective To investigate the correlation of plasma endothelin-1 (ET-1) and nitric oxide (NO) levels with arterial blood gas analysis,hemorheology and myocardial enzymology in acute exacerbation of pulmonary heart disease. Methods Thirty patients with acute exacerbation of pulmonary heart disease were selected as the observation group and 30 healthy subjects as the control group. On admission to hospital and after treatment for 2 weeks, venous blood samples were drawn for the detection of plasma ET-1 and NO levels, arterial blood gas parameters, hemodynamic indexes and myocardial enzymes. Results There were significant differences in plasma ET-1 and NO levels, hemodynamic indexes and myocardial enzymes between the two groups before treatment (P<0.05). In observation group, all indicators were obviously improved after treatment for 2 weeks (P<0.05). Pearson correlation analysis showed that plasma ET-1 and NO levels were negatively correlated with arterial PaO2 (r=-0.567 and -0.583, respectively; P<0.05), but positively correlated with PaCO2 (r=0.558 and 0.568, respectively; P<0.05), blood viscosity (r=0.602 and 0.587, respectively; P<0.05) and plasma viscosity (r=0.493 and 0.501, respectively; P<0.05). Conclusion The levels of plasma ET-1 and NO can be used as an important reference for evaluating the severity of disease and judging the prognosis in patients with acute exacerbation of pulmonary heart disease.