CAJ | 학술논문

目的：探讨右室 Tei指数评价双水平气道正压通气(BiPAP)治疗冠心病合并不同类型睡眠呼吸障碍的疗效。方法对2011年1月—2012年12月南京医科大学附属江宁医院呼吸科睡眠监测室进行多导睡眠监测(PSG)的人群进行筛选,共入选病人60例,根据 PSG检查结果分为中枢性 SDB组、阻塞性 SDB组、混合性 SDB组,每组20例。所有人群均测定 PSG指标[睡眠呼吸暂停低通气指数(AHI)、SaO2<90%时间]、右心功能指标(Tei指数)和血管内皮功能指标(内皮素1和一氧化氮)；病人经 BiPAP治疗并随访1个月,记录治疗前后的各项指标并比较。结果经 BiPAP治疗后,3组 PSG指标、右心功能及血管内皮功均能得到明显改善(P<0.05)。结论 BiPAP治疗能明显改善与呼吸暂停有关的低氧状态,从而调节血管内皮的功能,改善右心功能,可能会成为治疗冠心病合并 SDB的重要途径。
목적：탐토우실 Tei지수평개쌍수평기도정압통기(BiPAP)치료관심병합병불동류형수면호흡장애적료효。방법대2011년1월—2012년12월남경의과대학부속강저의원호흡과수면감측실진행다도수면감측(PSG)적인군진행사선,공입선병인60례,근거 PSG검사결과분위중추성 SDB조、조새성 SDB조、혼합성 SDB조,매조20례。소유인군균측정 PSG지표[수면호흡잠정저통기지수(AHI)、SaO2<90%시간]、우심공능지표(Tei지수)화혈관내피공능지표(내피소1화일양화담)；병인경 BiPAP치료병수방1개월,기록치료전후적각항지표병비교。결과경 BiPAP치료후,3조 PSG지표、우심공능급혈관내피공균능득도명현개선(P<0.05)。결론 BiPAP치료능명현개선여호흡잠정유관적저양상태,종이조절혈관내피적공능,개선우심공능,가능회성위치료관심병합병 SDB적중요도경。
Objective To explore the effects of Tei index on bi level positive airway pressure for treatment of coronary heart disease (CHD)patients with sleep disordered breathing (SDB).Methods Sixty patients tested with PSG were al ocated to central SDB group,obstructive SDB group and blend SDB group(20 cases per group).Al patients were tested with right heart function(Tei index)with 2D echo,vascular endothelial function(ET 1 and NO)and PSG index(AHI,LSaO2 ,the time of SaO2<90%).These measurements were repeated in patients one month later after BiPAP treatment and one month.Results The PSG index,right heart function and vascular endothelial function were significantly improved after BiPAP treatment in three groups.Conclusion BiPAP can improve hypoxia and vascular endothelial function,enhance right heart function and therefore may be useful in treatment of CHD with SDB.