CAJ | 학술논문

目的：通过静息态功能磁共振成像(rs-fMRI)技术对脑白质疏松(LA)轻度认知障碍(MCI)患者脑默认网络进行分析。方法 LA患者31例，临床痴呆评分(CDR)0.5；年龄、性别和受教育程度匹配的正常对照组27人， CDR为0。对入组人群进行rs-fMRI数据采集。使用SPM5软件进行分析处理，使用fMRI工具盒对预处理后的数据进行独立成分分析(ICA)，组间差异进行双样本t检验。结果静息状态下，对照组默认网络包括扣带回后部/楔前叶，双侧额叶内侧，双侧颞中回，双侧顶下回、角回，双侧海马。MCI组默认网络激活区域同对照组一致；同对照组相比，MCI患者扣带回前部/左侧额叶内侧、右侧海马旁回/钩回、右侧颞下回、左侧额叶深部白质/尾状核头部激活减低，左侧尾状核/扣带回前部、左侧额叶、左侧颞上回/顶下回的激活升高。结论LA患者静息状态默认网络活动异常，可能与认知障碍的发生有关。
목적：통과정식태공능자공진성상(rs-fMRI)기술대뇌백질소송(LA)경도인지장애(MCI)환자뇌묵인망락진행분석。방법 LA환자31례，림상치태평분(CDR)0.5；년령、성별화수교육정도필배적정상대조조27인， CDR위0。대입조인군진행rs-fMRI수거채집。사용SPM5연건진행분석처리，사용fMRI공구합대예처리후적수거진행독립성분분석(ICA)，조간차이진행쌍양본t검험。결과정식상태하，대조조묵인망락포괄구대회후부/설전협，쌍측액협내측，쌍측섭중회，쌍측정하회、각회，쌍측해마。MCI조묵인망락격활구역동대조조일치；동대조조상비，MCI환자구대회전부/좌측액협내측、우측해마방회/구회、우측섭하회、좌측액협심부백질/미상핵두부격활감저，좌측미상핵/구대회전부、좌측액협、좌측섭상회/정하회적격활승고。결론LA환자정식상태묵인망락활동이상，가능여인지장애적발생유관。
Objective To study the default mode network (DMN) of mild cognitive impairment (MCI) related to leukoaraiosis (LA) with resting-state functional magnetic resonance imaging (rs-fMRI). Methods 31 LA patients (Clinical Dementia Rating of 0.5) and 27 nor-mal controls (Clinical Dementia Rating of 0, and matched in age, gender and lever of education) were scanned with the rs-fMRI. The data was analyzed with SPM5 software, using independent component analysis. The differences between the both groups were compared with two-sample t-test. Results The DMN during resting-state of normal controls was posterior cingulate cortex/precuneus, bilateral medial fron-tal cortex, bilateral middle temporal gyrus, bilateral inferior parietal gyrus, angular gyrus, bilateral hippocampus. The DMN of MCI group was consistent with the normal controls, but the activation decreased in anterior cingulate cortex/left medial frontal lobe, right parahippcam-pus/uncus, right inferior temporal gyrus, left deep frontal white matter/head of caudate nucleus;and increased in the left caudate nucleus/an-terior cingulate cortex, left frontal lobe, and left superior temporal gyrus/inferior parietal gyrus. Conclusion Activation of resting-state func-tional network is disorder in LA, which may relate to cognitive impairment.