CAJ | 학술논문

目的探讨 T-SPOT.TB（结核感染 T 细胞斑点实验）试验在结核性脑膜炎诊断中的价值。方法对我院26例临床和影像学可疑结核性脑膜炎的患者的脑脊液实施结核感染 T 细胞斑点实验，对照组为23例无结核原发病灶的脑膜炎患者的脑脊液实施结核感染 T 细胞斑点实验。结果26例临床和影像学可疑结核性脑膜炎患者中，23例结核感染 T 细胞斑点实验阳性（占88.5%），对照组24例中结核感染 T 细胞斑点实验阳性有4人（占16.7%）。利用结核感染 T 细胞斑点实验检测以此诊断结核性脑膜炎的敏感度为88.5%（95%可信区间 CI 49.9～91.3）特异度为83.3%（95%可信区间 CI 69.3～97.8），阳性预测值为82.5%（95%可信区间 CI<br>　　72.6～97.9），阴性预测值为91.7%（95%可信区间 CI 48.3～97.1）。结论结核感染 T 细胞斑点实验是一种具有较高敏感性和特异性的检测结核感染的技术，这对快速而准确地诊断结核性脑膜炎是有用的。
목적탐토 T-SPOT.TB（결핵감염 T 세포반점실험）시험재결핵성뇌막염진단중적개치。방법대아원26례림상화영상학가의결핵성뇌막염적환자적뇌척액실시결핵감염 T 세포반점실험，대조조위23례무결핵원발병조적뇌막염환자적뇌척액실시결핵감염 T 세포반점실험。결과26례림상화영상학가의결핵성뇌막염환자중，23례결핵감염 T 세포반점실험양성（점88.5%），대조조24례중결핵감염 T 세포반점실험양성유4인（점16.7%）。이용결핵감염 T 세포반점실험검측이차진단결핵성뇌막염적민감도위88.5%（95%가신구간 CI 49.9～91.3）특이도위83.3%（95%가신구간 CI 69.3～97.8），양성예측치위82.5%（95%가신구간 CI<br>　　72.6～97.9），음성예측치위91.7%（95%가신구간 CI 48.3～97.1）。결론결핵감염 T 세포반점실험시일충구유교고민감성화특이성적검측결핵감염적기술，저대쾌속이준학지진단결핵성뇌막염시유용적。
Objective To analysis the value of T-SPOT.TB detection in the diagnosis of tuberculous meningitis. Methods Cerebrospinal fluid of 26 cases who clinical and radiographic suspected tuberculous meningitis was tested with T-SPOT.TB test.Cerebrospinal fluid of 24 cases of meningitis with no tuberculous was tested with T-SPOT.TB test as the control group. Results The T-SPOT.TB test was positive in 24 cases of the experimental group(92.3%),however,in control group only 3 was positive(12.5%).Using T-SPOT.TB test to diagnose tuberculous meningitis,the sensitivity was 92.3%(95% confidence interval CI 52.5 ~ 94.2),the specificity was 87.5%(95%CI 70.3 ~ 97.8),the positive predictive value was 83.5%(95% CI 72.6 ~ 97.9),and the negative predictive value was 94.7%(95%CI 48.3 ~ 97.1). Conclusion T-SPOT.TB ELISPOT is a method with high sensitivity and specificity to the detection of tuberculosis infection,which is useful to quick and accurate diagnose tuberculous meningitis.