上海医药
上海醫藥
상해의약
SHANGHAI MEDICAL & PHARMACEUTICAL JOURNAL
2014年
23期
71-72,80
,共3页
亚硫酸氢钠%盐酸甲氧氯普胺注射液%比色法%质量控制
亞硫痠氫鈉%鹽痠甲氧氯普胺註射液%比色法%質量控製
아류산경납%염산갑양록보알주사액%비색법%질량공제
sodium bisulifte%metoclopramide dihydrochloride%colorimetric method%quality control
目的：建立盐酸甲氧氯普胺注射液中抗氧剂亚硫酸氢钠的含量测定方法。方法：基于在SO2存在下能使酸性品红溶液褪色的原理，采用比色法在549 nm波长处测定吸光度,用标准曲线法测定含量。结果：无水亚硫酸钠在9.917～29.75mg/ml，吸光度的倒数与其浓度（以SO2计）呈良好的线性关系，r =0.999，平均回收率为99.3%。结论：该方法操作简单，结果准确可靠，可作为制剂中抗氧剂亚硫酸氢钠的含量测定。
目的：建立鹽痠甲氧氯普胺註射液中抗氧劑亞硫痠氫鈉的含量測定方法。方法：基于在SO2存在下能使痠性品紅溶液褪色的原理，採用比色法在549 nm波長處測定吸光度,用標準麯線法測定含量。結果：無水亞硫痠鈉在9.917～29.75mg/ml，吸光度的倒數與其濃度（以SO2計）呈良好的線性關繫，r =0.999，平均迴收率為99.3%。結論：該方法操作簡單，結果準確可靠，可作為製劑中抗氧劑亞硫痠氫鈉的含量測定。
목적：건립염산갑양록보알주사액중항양제아류산경납적함량측정방법。방법：기우재SO2존재하능사산성품홍용액퇴색적원리，채용비색법재549 nm파장처측정흡광도,용표준곡선법측정함량。결과：무수아류산납재9.917～29.75mg/ml，흡광도적도수여기농도（이SO2계）정량호적선성관계，r =0.999，평균회수솔위99.3%。결론：해방법조작간단，결과준학가고，가작위제제중항양제아류산경납적함량측정。
Objective: To develop a method for the determination of sodium bisulfite in metoclopramide dihydrochloride injection.Methods: Based on the fading of fuchsin acid solution in the present of SO2, a colorimetric method was established to be used for the determination of absorbance at the wavelength of 549 nm. The amount of sodium bisulifte in sample was calculated by reference to a calibration curve obtained.Results: The reciprocal of absorbance and the concentrations of anhydrous sodium sulifte (calculated based on sulfur dioxide) showed a good linear relationship over the range of 9.917~29.75mg/ml (r=0.999) with an average recovery of 99.3%.Conclusion: This method is simple and accurate and can be used for the determination of sodium bisulifte in metoclopramide dihydrochloride injection.
