上海医药
上海醫藥
상해의약
SHANGHAI MEDICAL & PHARMACEUTICAL JOURNAL
2014年
23期
45-48,52
,共5页
2型糖尿病%血管内皮%一氧化氮%内皮素
2型糖尿病%血管內皮%一氧化氮%內皮素
2형당뇨병%혈관내피%일양화담%내피소
type 2 diabetes mellitus%vascular endothelium%nitric oxide%endothelin
糖尿病和心血管疾病中的血管内皮功能障碍的特征是血管张力调节改变、活性氧族产生增多、炎症激活和屏障功能改变，内皮细胞通过分泌多种因子调节细胞黏附、平滑肌细胞增殖及血管张力。血管内皮功能损伤是糖尿病血管并发症发生的始动因素和主要病理生理学基础。本文综述了血管内皮功能障碍与2型糖尿病研究进展。
糖尿病和心血管疾病中的血管內皮功能障礙的特徵是血管張力調節改變、活性氧族產生增多、炎癥激活和屏障功能改變，內皮細胞通過分泌多種因子調節細胞黏附、平滑肌細胞增殖及血管張力。血管內皮功能損傷是糖尿病血管併髮癥髮生的始動因素和主要病理生理學基礎。本文綜述瞭血管內皮功能障礙與2型糖尿病研究進展。
당뇨병화심혈관질병중적혈관내피공능장애적특정시혈관장력조절개변、활성양족산생증다、염증격활화병장공능개변，내피세포통과분비다충인자조절세포점부、평활기세포증식급혈관장력。혈관내피공능손상시당뇨병혈관병발증발생적시동인소화주요병리생이학기출。본문종술료혈관내피공능장애여2형당뇨병연구진전。
Endothelial dysfunction associated with diabetes and cardiovascular disease is characterized by the changes in vasoregulation, the enhancement of the generation of reactive oxygen intermediates, the inflammatory activation and the alteration in barrier function. Endothelial cells produce a wide range of factors that can also regulate cellular adhesion, smooth muscle cell proliferation, and vascular tone. It is well known that endothelium dysfunction is an early manifestation in the development of diabetic vascular complications. This review focuses on a research progress on endothelial dysfunction and type 2 diabetes mellitus.
