CAJ | 학술논문

目的：探讨血清降钙素原（PCT）水平对全身炎症反应综合征（SIRS）患儿病情预后评估的临床意义。方法：采用前瞻性病例对照方法，选取68例确诊的SIRS患儿分为脓毒症组和非脓毒症组，入院后24 h内检测血清PCT水平，作小儿危重病例（PCIS）评分；评估SIRS患儿住院28 d内生存情况，根据患儿临床结局分为死亡组和存活组，采用Spearman法分析患儿血清PCT水平与PCIS评分的关系。结果：脓毒症组入院时的血清PCT水平明显高于非脓毒症组，而PCIS评分明显低于非脓毒症组患儿（P<0.05）；死亡组患儿血清PCT水平明显高于存活组患儿，PCIS评分明显低于存活组患儿（P<0.05）；血清PCT水平与PCIS评分呈显著负相关（r=-0.637, P<0.01）。结论：对SIRS患儿进行血清PCT水平监测，可有助于早期判断脓毒症和非脓毒症，可作为评估SIRS患儿病情预后的重要指标。
목적：탐토혈청강개소원（PCT）수평대전신염증반응종합정（SIRS）환인병정예후평고적림상의의。방법：채용전첨성병례대조방법，선취68례학진적SIRS환인분위농독증조화비농독증조，입원후24 h내검측혈청PCT수평，작소인위중병례（PCIS）평분；평고SIRS환인주원28 d내생존정황，근거환인림상결국분위사망조화존활조，채용Spearman법분석환인혈청PCT수평여PCIS평분적관계。결과：농독증조입원시적혈청PCT수평명현고우비농독증조，이PCIS평분명현저우비농독증조환인（P<0.05）；사망조환인혈청PCT수평명현고우존활조환인，PCIS평분명현저우존활조환인（P<0.05）；혈청PCT수평여PCIS평분정현저부상관（r=-0.637, P<0.01）。결론：대SIRS환인진행혈청PCT수평감측，가유조우조기판단농독증화비농독증，가작위평고SIRS환인병정예후적중요지표。
Objective:To investigate the clinical signiifcance of serum procalcitonin (PCT) levels in the assessment of the systemic inlfammatory response syndrome (SIRS) in children.Methods: Sixty-eight cases of children with SIRS were selected by a prospective case-control method and divided into a sepsis group and a non-sepsis group based on their exact infection. The levels of serum PCT were detected within 24 h after admission and pediatric critical illness (PCIS) score was performed. The survival of SIRS children in 28 days of hospitalization was assessed and they were divided into a death group and a survival group according to their clinical outcome and the relationship of serum PCT levels with PCIS score was analyzed by Spearman correlation analysis.Results:The serum PCT levels at admission were signiifcantly higher in the sepsis group than in the non-sepsis group while PCIS score was signiifcantly lower in the sepsis group (P<0.05). The levels of serum PCT were signiifcantly higher in the death group than in the survival group while PCIS score was signiifcantly lower in the death group (P<0.05). The serum PCT levels showed a signiifcant negative correlation with PCIS score (r=-0.637,P<0.01).Conclusion:The monitoring of serum PCT levels in SIRS children is of beneift to early diagnosis of sepsis and non-sepsis and they can be used as important indexes for the assessment of the prognosis of SIRS children.