CAJ | 학술논문

调试熔体静电纺聚乳酸(PLA)过程中的电压场和温度场的参数，对不同条件下的纤维膜进行测试，研究电压场与温度场与纤维直径间的关系，并评价熔体静电纺 PLA 膜的细胞毒性。以聚乳酸(PLA)为原料，采用熔体静电纺丝方法，电压调整在20~26 kV范围，空间温度在10~70℃之间，分别进行熔体纺丝实验，将制得的纤维膜进行细胞毒性评价。熔体静电纺丝PLA纤维的平均直径随电压的升高逐渐增大，当空间温度为50℃时，所得纤维平均直径为最小。细胞活力测试证实熔体静电纺PLA膜无细胞毒性，具有良好的组织工程材料的应用前景。
조시용체정전방취유산(PLA)과정중적전압장화온도장적삼수，대불동조건하적섬유막진행측시，연구전압장여온도장여섬유직경간적관계，병평개용체정전방 PLA 막적세포독성。이취유산(PLA)위원료，채용용체정전방사방법，전압조정재20~26 kV범위，공간온도재10~70℃지간，분별진행용체방사실험，장제득적섬유막진행세포독성평개。용체정전방사PLA섬유적평균직경수전압적승고축점증대，당공간온도위50℃시，소득섬유평균직경위최소。세포활력측시증실용체정전방PLA막무세포독성，구유량호적조직공정재료적응용전경。
The PLA films were fabricated under the different voltage and temperature by melt electrospinning. Then they were characterized to examine the relationship between the parameters and fiber diameter.The vitro test is to investigate cytotoxicity of PLA membrane by melt electrospinning.With polylactic acid (PLA)as the raw material,the voltage of melt electrosspinning was adjusted from 20 to 26 kV and temperature was arranged between 10-70 ℃respectively and then to evaluate the cytotoxicity in vitro.Experimental results show that the mean diameter of PLA fiber become thicker with the increase of voltage.The average fiber diameter is minimum when the room temperature arrived at 50 ℃.PLA membrane by melt electrospinning is proved to be no cytotox-icity and has a good application prospects as tissue engineering materials.