目的：：研究妊娠糖尿病患者血清脂联素( APN)水平变化及其炎症因子、胰岛素抵抗的关系。方法：选取2012年6月至2014年6月产检孕妇为妊娠组( n=110例),根据糖耐量的结果将孕妇分为妊娠糖尿病组( n=48例)和非妊娠糖尿病组( n=62例),另选取非妊娠的健康育龄妇女为对照组( n=60例),应用酶联免疫吸附实验( ELISA)检测入选者的APN、肿瘤坏死因子-a( TNF-a)、白细胞介素( IL)-6,应用免疫比浊法测定高敏C反应蛋白( hs-CRP )的水平,并测定所有入选者的空腹胰岛素( Fins)、稳态胰岛素评估模型胰岛素抵抗( HOMA-IR)以及甘油三脂水平。结果：妊娠组血清IL-6、hs-CRP、TNF-a、TG、Fins和HOMA-IR分为为(29.1±0.4)pg/mL、(4.3±0.2)ng/mL、(31.3±0.5)pg/mL、(1.8±0.1)mmoL/L、(9.4±0.2)mU/L、(2.1±0.3)均显著高于对照组,比较差异具有统计学意义(t=8.792,9.173,9.068,10.026,9.957,9.819,P=0.038,0.027,0.029,0.021,0.023,0.025),APN水平(10.2±0.2)mg/L显著低于对照组,比较差异具有统计学意义(t=8.968,P=0.032)；妊娠糖尿病组血清IL-6、hs-CRP、TNF-a和HOMA-IR分别为(36.1±0.3)pg/mL、(6.9±0.3)ng/mL、(46.7±0.9)pg/mL和(3.0±0.2)显著高于非妊娠糖尿病组,两组比较差异具有统计学意义( t=10.021,9.796,8.935,9.012,P=0.026,0.031,0.034,0.029),APN水平(7.1±0.2)mg/L显著低于非妊娠糖尿病组,比较差异具有统计学意义(t=9.052,P=0.019)；APN和IL-6、hs-CRP、TNF-a、TG、Fins、HOMA-IR具有负相关关系( r=-0.389,-0.381,-0.382,-0.402,-0.391,P=0.019,0.023,0.025,0.018,0.031)。结论：妊娠糖尿病患者的APN水平会显著降低,会引起炎症反应失衡,可能是胰岛素抵抗的重要因素。
目的：：研究妊娠糖尿病患者血清脂聯素( APN)水平變化及其炎癥因子、胰島素牴抗的關繫。方法：選取2012年6月至2014年6月產檢孕婦為妊娠組( n=110例),根據糖耐量的結果將孕婦分為妊娠糖尿病組( n=48例)和非妊娠糖尿病組( n=62例),另選取非妊娠的健康育齡婦女為對照組( n=60例),應用酶聯免疫吸附實驗( ELISA)檢測入選者的APN、腫瘤壞死因子-a( TNF-a)、白細胞介素( IL)-6,應用免疫比濁法測定高敏C反應蛋白( hs-CRP )的水平,併測定所有入選者的空腹胰島素( Fins)、穩態胰島素評估模型胰島素牴抗( HOMA-IR)以及甘油三脂水平。結果：妊娠組血清IL-6、hs-CRP、TNF-a、TG、Fins和HOMA-IR分為為(29.1±0.4)pg/mL、(4.3±0.2)ng/mL、(31.3±0.5)pg/mL、(1.8±0.1)mmoL/L、(9.4±0.2)mU/L、(2.1±0.3)均顯著高于對照組,比較差異具有統計學意義(t=8.792,9.173,9.068,10.026,9.957,9.819,P=0.038,0.027,0.029,0.021,0.023,0.025),APN水平(10.2±0.2)mg/L顯著低于對照組,比較差異具有統計學意義(t=8.968,P=0.032)；妊娠糖尿病組血清IL-6、hs-CRP、TNF-a和HOMA-IR分彆為(36.1±0.3)pg/mL、(6.9±0.3)ng/mL、(46.7±0.9)pg/mL和(3.0±0.2)顯著高于非妊娠糖尿病組,兩組比較差異具有統計學意義( t=10.021,9.796,8.935,9.012,P=0.026,0.031,0.034,0.029),APN水平(7.1±0.2)mg/L顯著低于非妊娠糖尿病組,比較差異具有統計學意義(t=9.052,P=0.019)；APN和IL-6、hs-CRP、TNF-a、TG、Fins、HOMA-IR具有負相關關繫( r=-0.389,-0.381,-0.382,-0.402,-0.391,P=0.019,0.023,0.025,0.018,0.031)。結論：妊娠糖尿病患者的APN水平會顯著降低,會引起炎癥反應失衡,可能是胰島素牴抗的重要因素。
목적：：연구임신당뇨병환자혈청지련소( APN)수평변화급기염증인자、이도소저항적관계。방법：선취2012년6월지2014년6월산검잉부위임신조( n=110례),근거당내량적결과장잉부분위임신당뇨병조( n=48례)화비임신당뇨병조( n=62례),령선취비임신적건강육령부녀위대조조( n=60례),응용매련면역흡부실험( ELISA)검측입선자적APN、종류배사인자-a( TNF-a)、백세포개소( IL)-6,응용면역비탁법측정고민C반응단백( hs-CRP )적수평,병측정소유입선자적공복이도소( Fins)、은태이도소평고모형이도소저항( HOMA-IR)이급감유삼지수평。결과：임신조혈청IL-6、hs-CRP、TNF-a、TG、Fins화HOMA-IR분위위(29.1±0.4)pg/mL、(4.3±0.2)ng/mL、(31.3±0.5)pg/mL、(1.8±0.1)mmoL/L、(9.4±0.2)mU/L、(2.1±0.3)균현저고우대조조,비교차이구유통계학의의(t=8.792,9.173,9.068,10.026,9.957,9.819,P=0.038,0.027,0.029,0.021,0.023,0.025),APN수평(10.2±0.2)mg/L현저저우대조조,비교차이구유통계학의의(t=8.968,P=0.032)；임신당뇨병조혈청IL-6、hs-CRP、TNF-a화HOMA-IR분별위(36.1±0.3)pg/mL、(6.9±0.3)ng/mL、(46.7±0.9)pg/mL화(3.0±0.2)현저고우비임신당뇨병조,량조비교차이구유통계학의의( t=10.021,9.796,8.935,9.012,P=0.026,0.031,0.034,0.029),APN수평(7.1±0.2)mg/L현저저우비임신당뇨병조,비교차이구유통계학의의(t=9.052,P=0.019)；APN화IL-6、hs-CRP、TNF-a、TG、Fins、HOMA-IR구유부상관관계( r=-0.389,-0.381,-0.382,-0.402,-0.391,P=0.019,0.023,0.025,0.018,0.031)。결론：임신당뇨병환자적APN수평회현저강저,회인기염증반응실형,가능시이도소저항적중요인소。
Objective:To study the relationship of adiponectin levels in serum and inflammatory cyto-kines, insulin resistance of gestational diabetes. Method: 110 pregnant were selected as pregnancy group from our hospital from June 2012 to June 2014, they were divided into gestational diabetes group ( n = 48 patients) and non-pregnant diabetic group ( n = 62 patients) according to the results of glucose tolerance, healthy women of child bearing age were also selected as the control group(n = 60 patients), the APN, tumor necrosis factor-a ( TNF-a), interleukin ( IL) -6 of inductees were detected in enzyme-linked immu-nosorbent assay ( ELISA), the level of high-sensitivity C-reactive protein ( hs-CRP ) were detected in im-munoturbidimetry, the fasting insulin ( Fins ), homeostasis model assessment of insulin resistance insulin ( HOMA-IR) and triglyceride level of all inductees were detected. Result: The level of IL-6, hs-CRP, TNF-a, TG, Fins and HOMA-IR of the pregnancy group were (29.1 ± 0.4) pg / mL, (4.3 ± 0.2) ng /mL, (31.3 ± 0.5) pg / mL, (1.8 ± 0.1) mmoL / L, (9.4 ± 0.2) mU / L, (2.1 ± 0.3) significantly high-er than the control group, the difference was statistically significant(t=8.792,9.173,9.068,10.026,9.957, 9.819,P=0.038,0.027,0.029,0.021,0.023,0.025), the level of APN was (10.2±0.2)mg/L significantly lower than the control group, the difference was statistically significant ( t=8.968,P=0.032);the IL-6, hs-CRP, TNF-a and HOMA-IR of the gestational diabetes group were (36.1 ± 0.3) pg / mL, (6.9 ± 0.3) ng/ mL, (46.7 ± 0.9) pg / mL and (3.0 ± 0.2) significantly higher than the non-pregnant diabetic group, the difference was statistically significant(t=10.021,9.796,8.935,9.012,P=0.026,0.031,0.034,0.029), the level of APN was (7.1±0.2)mg/L,which was significantly lower than the non-pregnant diabetic group, the difference was statistically significant( t=9.052,P=0.019); APN and IL-6, hs-CRP, TNF-a, TG, Fins, HOMA-IR had a negative correlation( r=-0.389,-0.381,-0.382,-0.402,-0.391,P=0.019,0.023, 0.025,0.018,0.031). Conclusion: The level of APN of gestational diabetes can significantly reduce, can cause inflammation imbalance, may be an important factor in insulin resistance.
