CAJ | 학술논문

目的：：分析哮喘急性发作期、缓解期患儿血清 IL-4及 IgE 水平,探讨其临床意义。方法：选择35例支气管哮喘急性发作期患儿为观察组,35例支气管哮喘缓解期患儿为对照组,35例健康儿童为健康组。检查并比较各组IL-4、IgE水平及肺功能,分析其相关性。结果：观察组与对照组IL-4及IgE水平均显著高于健康组,差异均具有统计学意义( P<0.05)。且观察组IL-4及IgE水平也显著高于对照组,差异均具有统计学意义( P<0.05)。观察组FEV1及PEF均显著低于对照组,差异具有统计学意义( P<0.05)。经person相关分析,哮喘发作期及缓解期患儿IL-4、IgE与FEV1及PEF间均存在显著负相关( r=-0.786,-0.658,-0.865,-0.852,P<0.05)。结论：支气管哮喘患儿急性发作期IL-4及IgE水平显著升高,肺功能相关指标明显降低,细胞因子IL-4及免疫球蛋白IgE水平与患儿肺功能间存在显著负相关。
목적：：분석효천급성발작기、완해기환인혈청 IL-4급 IgE 수평,탐토기림상의의。방법：선택35례지기관효천급성발작기환인위관찰조,35례지기관효천완해기환인위대조조,35례건강인동위건강조。검사병비교각조IL-4、IgE수평급폐공능,분석기상관성。결과：관찰조여대조조IL-4급IgE수평균현저고우건강조,차이균구유통계학의의( P<0.05)。차관찰조IL-4급IgE수평야현저고우대조조,차이균구유통계학의의( P<0.05)。관찰조FEV1급PEF균현저저우대조조,차이구유통계학의의( P<0.05)。경person상관분석,효천발작기급완해기환인IL-4、IgE여FEV1급PEF간균존재현저부상관( r=-0.786,-0.658,-0.865,-0.852,P<0.05)。결론：지기관효천환인급성발작기IL-4급IgE수평현저승고,폐공능상관지표명현강저,세포인자IL-4급면역구단백IgE수평여환인폐공능간존재현저부상관。
Objective:To analyze the serum IL-4 and IgE levels of acute attack asthma and remission period asthma, to explore the clinical significance. Method:35 cases of acute attack bronchial asthma were as the observation group, 35 cases of bronchial asthma in remission stage were as control group, 35 healthy children as healthy group. IL-4,IgE levels and lung function in 3 groups were detected and compared, the correlation were analyzed. Result: IL-4 and IgE levels in observation group and control group were signifi-cantly higher than healthy group, The differences were statistically significant (P<0.05).The level of IgE and IL-4 in observation group was significantly higher than that in control group, The differences were statis-tically significant (P < 0.05). The FEV1 and PEF of the observation group were significantly lower than those in the control group, The difference was statistically significant ( P<0.05) . The person correlation anal-ysis showed that there were significant negative correlation among IL-4, IgE levels and FEV1 and PEF( r=-0.786, -0.658,-0.865,-0.852, P<0.05). Conclusion:IL-4 and IgE levels in children with acute attack bronchial asthma significantly elevated, lung function decreased, There's significant negative correlation be-tween IL-4 and immunoglobulin IgE levels and lung function in children with cytokines.