CAJ | 학술논문

目的：：探讨不同剂量阿司匹林在冠脉支架置入术后抗血小板的有效性及安全性。方法：选择患者80例,分为两组,各40例,低剂量组采用阿司匹林100mg/d,高剂量组则采用阿司匹林300mg/d,比较两组患者治疗后肿瘤坏死因子-a、白细胞介素-6及超敏C反应蛋白水平,并统计两组发生临床死亡、再梗死率及脑卒中发生率,并分析异常出血情况。结果：治疗后高剂量组肿瘤坏死因子-a、超敏C反应蛋白及白细胞介素-6水平显著低于低剂量组( P<0.05),高剂量组发生临床死亡、再发心梗及脑卒中的比例显著低于低剂量组( P<0.05),高剂量组发生局部血肿、穿刺部位渗血、黑便、柏油样便及牙龈出血的比例显著低于低剂量组( P<0.05)。结论：冠状动脉介入术后使用300mg/d阿司匹林抗血小板,能有效降低机体炎症水平,预防心脑血管事件发生,且不增加出血相关并发症。
목적：：탐토불동제량아사필림재관맥지가치입술후항혈소판적유효성급안전성。방법：선택환자80례,분위량조,각40례,저제량조채용아사필림100mg/d,고제량조칙채용아사필림300mg/d,비교량조환자치료후종류배사인자-a、백세포개소-6급초민C반응단백수평,병통계량조발생림상사망、재경사솔급뇌졸중발생솔,병분석이상출혈정황。결과：치료후고제량조종류배사인자-a、초민C반응단백급백세포개소-6수평현저저우저제량조( P<0.05),고제량조발생림상사망、재발심경급뇌졸중적비례현저저우저제량조( P<0.05),고제량조발생국부혈종、천자부위삼혈、흑편、백유양편급아간출혈적비례현저저우저제량조( P<0.05)。결론：관상동맥개입술후사용300mg/d아사필림항혈소판,능유효강저궤체염증수평,예방심뇌혈관사건발생,차불증가출혈상관병발증。
Objective:To investigate the efficacy and safety of aspirin in antiplatelet for coronary stent-ing with different doses. Method:80 cases were divided into two groups, each with 40 cases,the low dose group was used 100mg/d, high dose group was used aspirin with 300mg/d, then patients after tumor necrosis factor -a, IL interleukin-6 and high-sensitivity C-reactive protein levels and abnormal bleeding statistical groups of clinical death, reinfarction and stroke incidence rates were compared in the two groups.Result:Af-ter treatment,tumor necrosis factor-a, levels of high-sensitivity C-reactive protein and interleukin-6 were significantly lower than low-dose group (P<0.05), clinical death occurred and the proportion of recurrent myocardial infarction and stroke in the high dose group were significantly lower than the low-dose group( P<0.05) , the high dose group with localized hematoma puncture site bleeding, black stools, tarry stools and gingival bleeding were significantly lower than the low dose group ( P<0.05) . Conclusion:After coronary in-tervention use 300mg / d of aspirin antiplatelet can effectively reduce the level of inflammation, it can pre-vent cardiovascular events and,it is without increasing bleeding-related complications.