CAJ | 학술논문

目的比较来曲唑和克罗米酚在原因不明不孕症患者的宫腔内人工受精（IUI）治疗过程中的临床效果。方法回顾性分析2011年1月至2012年12月于本教学医院生殖医学中心接受IUI治疗的原因不明不孕症患者共201例。其中使用来曲唑促排卵的IUI周期173例，使用克罗米酚促排卵的IUI周期28例，比较两组促排卵效果和IUI临床结局。结果克罗米酚组患者促排卵后获得直径>14mm卵泡数较多，雌激素峰值较高。两组其他促排卵参数差异无显著性。来曲唑组临床妊娠率、活产率高于克罗米酚组，但该差异无显著性。结论在原因不明不孕症患者的IUI治疗中，来曲唑和克罗米酚的临床效果相近。
목적비교래곡서화극라미분재원인불명불잉증환자적궁강내인공수정（IUI）치료과정중적림상효과。방법회고성분석2011년1월지2012년12월우본교학의원생식의학중심접수IUI치료적원인불명불잉증환자공201례。기중사용래곡서촉배란적IUI주기173례，사용극라미분촉배란적IUI주기28례，비교량조촉배란효과화IUI림상결국。결과극라미분조환자촉배란후획득직경>14mm란포수교다，자격소봉치교고。량조기타촉배란삼수차이무현저성。래곡서조림상임신솔、활산솔고우극라미분조，단해차이무현저성。결론재원인불명불잉증환자적IUI치료중，래곡서화극라미분적림상효과상근。
Objective To compare the clinical effect of Letrozole and Clomiphene in ovulation induction with IUI cycles of the patients with unexplained infertility.Method This was a retrospective cohort study of the patients who underwent ovulation induction with IUI treatment, between Jan. 2011 and Dec. 2012, in a university hospital. A total of 201 IUI cycles were included. The Letrozole group included 173 IUI cycles, while 28 cycles with Clomiphene constituted as the Clomiphene group. Ovulation induction performance and IUI outcome were compared between the two groups.Result The number of follicles with diameter>14mm and the peak E2 level were higher in Clomiphene group compared with the Letrozole Group. No differences were found in other ovulation induction parameters. Patients undergoing ovulation induction with Letrozole and those with Clomiphene obtained comparable IUI outcomes, in terms of pregnancy rate and live birth rate.Conclusion This study suggests similar clinical effects of Letrozole and Clomiphene in patients with unexplained infertility.