南方医科大学学报
南方醫科大學學報
남방의과대학학보
JOURNAL OF SOUTHERN MEDICAL UNIVERSITY
2014年
10期
1481-1487
,共7页
非酒精性脂肪性肝病%脂联素受体2基因+33371Gln/Arg%细胞色素P4502E1基因RsaⅠ位点%多态现象%吸烟
非酒精性脂肪性肝病%脂聯素受體2基因+33371Gln/Arg%細胞色素P4502E1基因RsaⅠ位點%多態現象%吸煙
비주정성지방성간병%지련소수체2기인+33371Gln/Arg%세포색소P4502E1기인RsaⅠ위점%다태현상%흡연
nonalcoholic fatty liver disease%adiponectin receptor 2 gene + 33371Gln/Arg%cytochrome P4502E1 gene Rsa Ⅰ%polymorphism%smoking
目的 探讨脂联素受体2(AdipoR2)基因+33371Gln/Arg、细胞色素P4502E1 (CYP2E1)基因Rsa Ⅰ位点多态性和吸烟与非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)发病之间的关系.方法 采用病例-鹏研院的方法,以750例NAFLD患者及750例健康对照者的外周血白细胞为样本,利用聚合酶链反应(polymerase chain reaction,PCR)技术分析了+33371Gln/Arg和CYP2E 1-RsaⅠ基因多态性.结果 +33371Gln/Arg(A/A)基因型和CYP2E1-Rsa Ⅰ (c2/c2)基因型频率分布分别为39.20％、71.73％(病例组)和21.07％、43.07％(对照组).+33371Gln/Arg(A/A)患NAFLD的风险显著增加(OR=2.4156,95％CI=1.8164～4.0725).CYP2E1-saⅠ (c2/c2)基因型者患NAFLD的风险也显著增加(OR=3.3547,95％CI=1.9182～4.5057).+33371Gln/Arg(A/A)/CYP2E1-RsaⅠ(c2/c2)基因型者在NAFLD组和对照组中的分布频率分别为32.67％和6.40％.+33371Gln/Arg(A/A)/CYP2E1-Rsa Ⅰ (c2/c2)基因型者患NAFLD的风险显著增加(OR=9.9264,95％CI=4.2928～12.4241).病例组的吸烟率显著高于对照组的吸烟率(OR=2.5919,95％CI=1.4194～4.9528),+33371Gln/Arg(A/A)/CYP2E1-RsaⅠ (c2/c2)基因型与吸烟有协同作用(OR=34.6764,95％CI=18.9076～61.5825).结论 +33371Gln/Arg(A/A)/CYP2E1-Rsa Ⅰ (c2/c2)基因型和吸烟是NAFLD的易患因素,三者的联合在NAFLD的发生中起着协同的作用.
目的 探討脂聯素受體2(AdipoR2)基因+33371Gln/Arg、細胞色素P4502E1 (CYP2E1)基因Rsa Ⅰ位點多態性和吸煙與非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)髮病之間的關繫.方法 採用病例-鵬研院的方法,以750例NAFLD患者及750例健康對照者的外週血白細胞為樣本,利用聚閤酶鏈反應(polymerase chain reaction,PCR)技術分析瞭+33371Gln/Arg和CYP2E 1-RsaⅠ基因多態性.結果 +33371Gln/Arg(A/A)基因型和CYP2E1-Rsa Ⅰ (c2/c2)基因型頻率分佈分彆為39.20％、71.73％(病例組)和21.07％、43.07％(對照組).+33371Gln/Arg(A/A)患NAFLD的風險顯著增加(OR=2.4156,95％CI=1.8164～4.0725).CYP2E1-saⅠ (c2/c2)基因型者患NAFLD的風險也顯著增加(OR=3.3547,95％CI=1.9182～4.5057).+33371Gln/Arg(A/A)/CYP2E1-RsaⅠ(c2/c2)基因型者在NAFLD組和對照組中的分佈頻率分彆為32.67％和6.40％.+33371Gln/Arg(A/A)/CYP2E1-Rsa Ⅰ (c2/c2)基因型者患NAFLD的風險顯著增加(OR=9.9264,95％CI=4.2928～12.4241).病例組的吸煙率顯著高于對照組的吸煙率(OR=2.5919,95％CI=1.4194～4.9528),+33371Gln/Arg(A/A)/CYP2E1-RsaⅠ (c2/c2)基因型與吸煙有協同作用(OR=34.6764,95％CI=18.9076～61.5825).結論 +33371Gln/Arg(A/A)/CYP2E1-Rsa Ⅰ (c2/c2)基因型和吸煙是NAFLD的易患因素,三者的聯閤在NAFLD的髮生中起著協同的作用.
목적 탐토지련소수체2(AdipoR2)기인+33371Gln/Arg、세포색소P4502E1 (CYP2E1)기인Rsa Ⅰ위점다태성화흡연여비주정성지방성간병(nonalcoholic fatty liver disease,NAFLD)발병지간적관계.방법 채용병례-붕연원적방법,이750례NAFLD환자급750례건강대조자적외주혈백세포위양본,이용취합매련반응(polymerase chain reaction,PCR)기술분석료+33371Gln/Arg화CYP2E 1-RsaⅠ기인다태성.결과 +33371Gln/Arg(A/A)기인형화CYP2E1-Rsa Ⅰ (c2/c2)기인형빈솔분포분별위39.20％、71.73％(병례조)화21.07％、43.07％(대조조).+33371Gln/Arg(A/A)환NAFLD적풍험현저증가(OR=2.4156,95％CI=1.8164～4.0725).CYP2E1-saⅠ (c2/c2)기인형자환NAFLD적풍험야현저증가(OR=3.3547,95％CI=1.9182～4.5057).+33371Gln/Arg(A/A)/CYP2E1-RsaⅠ(c2/c2)기인형자재NAFLD조화대조조중적분포빈솔분별위32.67％화6.40％.+33371Gln/Arg(A/A)/CYP2E1-Rsa Ⅰ (c2/c2)기인형자환NAFLD적풍험현저증가(OR=9.9264,95％CI=4.2928～12.4241).병례조적흡연솔현저고우대조조적흡연솔(OR=2.5919,95％CI=1.4194～4.9528),+33371Gln/Arg(A/A)/CYP2E1-RsaⅠ (c2/c2)기인형여흡연유협동작용(OR=34.6764,95％CI=18.9076～61.5825).결론 +33371Gln/Arg(A/A)/CYP2E1-Rsa Ⅰ (c2/c2)기인형화흡연시NAFLD적역환인소,삼자적연합재NAFLD적발생중기착협동적작용.
