CAJ | 학술논문

目的：探讨小儿神经母细胞瘤组织中同源盒基因（ HOX） C9蛋白的表达与肿瘤发展及预后的关系。方法神经母细胞瘤患儿112例，手术中留取肿瘤组织，免疫组化染色法检测瘤组织中的HOXC9蛋白，分析其表达与神经母细胞瘤临床病理参数的关系；随访78例患儿，通过Kaplan-Merier法建立生存曲线，分析HOXC9蛋白表达量与患儿生存时间的关系。结果神经母细胞瘤组织中HOXC9蛋白的表达与患儿年龄及肿瘤临床病理分期、细胞分化程度、转移情况有关（P均＜0．05）；HOXC9蛋白表达与神经母细胞瘤患儿的生存时间有关（P＜0．01）。结论 HOXC9蛋白与神经母细胞瘤的发展和预后相关。
목적：탐토소인신경모세포류조직중동원합기인（ HOX） C9단백적표체여종류발전급예후적관계。방법신경모세포류환인112례，수술중류취종류조직，면역조화염색법검측류조직중적HOXC9단백，분석기표체여신경모세포류림상병리삼수적관계；수방78례환인，통과Kaplan-Merier법건립생존곡선，분석HOXC9단백표체량여환인생존시간적관계。결과신경모세포류조직중HOXC9단백적표체여환인년령급종류림상병리분기、세포분화정도、전이정황유관（P균＜0．05）；HOXC9단백표체여신경모세포류환인적생존시간유관（P＜0．01）。결론 HOXC9단백여신경모세포류적발전화예후상관。
Objective To explore the correlation between the expression of homeobox genes ( HOX) C9 protein in neuroblastoma of children and the development as well as prognosis of tumor .Methods Collected specimens of surgical tumor tissues from 112 cases with neuroblastoma , to observe the expression of HOXC 9 protein by assay of immunohisto-chemical staining and analyze the association between the expression and clinicopathological feature of neuroblastoma .Fol-lowed up with 78 children, then established the survival curve with method of Kaplan-Merier and certificated the expression quantity of HOXC9 protein and survival time in children .Results The level of HOXC9 protein expression in neuroblasto-ma was associated with several factors , such as age of child , clinical tumor-node-metastasis stage , cell differentiation grade and metastasis status(all P<0.05).Expression of HOXC9 protein was identified correlated with survival time of children in neuroblastoma(P<0.01).Conclusion HOXC9 protein is in association with the development and prognosis of neuro-blastoma.