中国医院用药评价与分析
中國醫院用藥評價與分析
중국의원용약평개여분석
EVALUATION AND ANAL YSIS OF DRUG-USE IN HOSPITALS OF CHINA
2014年
12期
1123-1125,1126
,共4页
药品不良反应%回顾性研究%分析
藥品不良反應%迴顧性研究%分析
약품불량반응%회고성연구%분석
Adverse drug reaction%Retrospective study%Analysis
目的：探讨解放军第175医院（以下简称“我院”）药品不良反应（ ADR）发生的特点及规律，为临床合理用药提供参考，避免严重的ADR重复发生。方法：采用回顾性研究方法，对我院2013年上报的329例合格的ADR报告进行统计、分析。结果：329例ADR报告中，新的 ADR 为6例，占1?82％，严重的 ADR 为65例，占19?76％；引发 ADR 的给药方式以静脉给药为主（100例，占30?40％”）；男性165例，女性139例，25例性别不详；304例已知性别的患者中，41～80岁223例，占73?36％，而20岁以下患者仅22例，占7?24％；抗肿瘤药引起的ADR为76例，占总报告数的23?10％，抗菌药物引起的ADR为54例，占总报告数的16?41％，中药注射剂引起的ADR为27例，占总报告数的8?21％；ADR临床表现主要为消化系统、神经系统、皮肤及其附件损害等。结论：应加强ADR监测，选择合适的药物、剂型和给药途径，加强用药监护，特别是加强对老年人、儿童、肝肾功能不全患者等特殊人群）的用药监护，促进临床合理用药，避免或减少一些严重的ADR重复出现。
目的：探討解放軍第175醫院（以下簡稱“我院”）藥品不良反應（ ADR）髮生的特點及規律，為臨床閤理用藥提供參攷，避免嚴重的ADR重複髮生。方法：採用迴顧性研究方法，對我院2013年上報的329例閤格的ADR報告進行統計、分析。結果：329例ADR報告中，新的 ADR 為6例，佔1?82％，嚴重的 ADR 為65例，佔19?76％；引髮 ADR 的給藥方式以靜脈給藥為主（100例，佔30?40％”）；男性165例，女性139例，25例性彆不詳；304例已知性彆的患者中，41～80歲223例，佔73?36％，而20歲以下患者僅22例，佔7?24％；抗腫瘤藥引起的ADR為76例，佔總報告數的23?10％，抗菌藥物引起的ADR為54例，佔總報告數的16?41％，中藥註射劑引起的ADR為27例，佔總報告數的8?21％；ADR臨床錶現主要為消化繫統、神經繫統、皮膚及其附件損害等。結論：應加彊ADR鑑測，選擇閤適的藥物、劑型和給藥途徑，加彊用藥鑑護，特彆是加彊對老年人、兒童、肝腎功能不全患者等特殊人群）的用藥鑑護，促進臨床閤理用藥，避免或減少一些嚴重的ADR重複齣現。
목적：탐토해방군제175의원（이하간칭“아원”）약품불량반응（ ADR）발생적특점급규률，위림상합리용약제공삼고，피면엄중적ADR중복발생。방법：채용회고성연구방법，대아원2013년상보적329례합격적ADR보고진행통계、분석。결과：329례ADR보고중，신적 ADR 위6례，점1?82％，엄중적 ADR 위65례，점19?76％；인발 ADR 적급약방식이정맥급약위주（100례，점30?40％”）；남성165례，녀성139례，25례성별불상；304례이지성별적환자중，41～80세223례，점73?36％，이20세이하환자부22례，점7?24％；항종류약인기적ADR위76례，점총보고수적23?10％，항균약물인기적ADR위54례，점총보고수적16?41％，중약주사제인기적ADR위27례，점총보고수적8?21％；ADR림상표현주요위소화계통、신경계통、피부급기부건손해등。결론：응가강ADR감측，선택합괄적약물、제형화급약도경，가강용약감호，특별시가강대노년인、인동、간신공능불전환자등특수인군）적용약감호，촉진림상합리용약，피면혹감소일사엄중적ADR중복출현。
OBJECTIVE:To investigate the characteristics and regularity of the adverse drug reactions ( ADRs) in No?175 Hospital of PLA ( hereinafter referred to as “our hospital”) for clinical reference of rational use of drugs and prevention of the repeated occurrence of ADRs. METHODS:By a retrospective study, a total of 329 eligible ADR case reports collected in our hospital in 2013 were statistically analyzed. RESULTS: Of the 329 ADR cases, 6(1?82%) were new ADR cases and 65(19?76%) serious ones;100(30?40%) were induced intravenously;165 were males vs. 139 females with unknown gender for the another 25 cases;of the 304 gender?known cases, 223(73?36%) aged 41?80 years and 22 ( 7?24%) below 20 years; 76 ( 23?10%) were induced by anti?tumor drugs, 54 ( 16?41%) by antibiotics and 27 ( 8?21%) by traditional Chinese medicine injections, which should be given great attention clinically. The ADRs manifested mainly as lesions of digestive system, nervous system and skin and its appendants etc. CONCLUSIONS:It is important to strengthen ADR monitoring, properly choose drugs, dosage form and routes of administration, strengthen medication monitoring for patients, especially for the special population including the elderly and children and those with hepatorenal insufficiency to promote rational use of drugs and prevent or reduce the repeated occurrence of serious ADRs.
