中国医院用药评价与分析
中國醫院用藥評價與分析
중국의원용약평개여분석
EVALUATION AND ANAL YSIS OF DRUG-USE IN HOSPITALS OF CHINA
2014年
12期
1093-1095,1096
,共4页
质子泵抑制剂%消化道出血%应激性溃疡%系统评价%Meta分析
質子泵抑製劑%消化道齣血%應激性潰瘍%繫統評價%Meta分析
질자빙억제제%소화도출혈%응격성궤양%계통평개%Meta분석
Proton pump inhibitor%Alimentary tract hemorrhage%Systematic review%Meta-analysis
目的:系统评价质子泵抑制剂治疗应激性溃疡疗效与安全性,以期为临床应用提供更优化的方案。方法:用计算机检索中国学术期刊全文数据库( CNKI)、万方中文期刊全文数据库( WanFang Data)、重庆维普中文期刊全文数据库( VIP),检索时间为1998—2013年。共检索出192个随机对照试验( randomized controlled trial,RCT),排除不符合的文献后,使用RevMan 5?0软件进行荟萃分析(Meta分析)。结果:共纳入8个RCT、637例应激性溃疡患者。观察组止血疗效高于对照组(OR=3?83,95%CI=1?90~7?70,P<0?0002);治疗后,观察组患者胃液pH值高于对照组(MD=1?96,95%CI=1?89~2?04,P<0?00001);观察组患者平均止血时间短于对照组(MD=1?95,95%CI=1?87~2?03,P<0?00001);纳入的文献均描述2组参与者未见不良反应。结论:质子泵抑制剂在治疗应激性溃疡方面有良好的疗效和安全性,值得推广应用。
目的:繫統評價質子泵抑製劑治療應激性潰瘍療效與安全性,以期為臨床應用提供更優化的方案。方法:用計算機檢索中國學術期刊全文數據庫( CNKI)、萬方中文期刊全文數據庫( WanFang Data)、重慶維普中文期刊全文數據庫( VIP),檢索時間為1998—2013年。共檢索齣192箇隨機對照試驗( randomized controlled trial,RCT),排除不符閤的文獻後,使用RevMan 5?0軟件進行薈萃分析(Meta分析)。結果:共納入8箇RCT、637例應激性潰瘍患者。觀察組止血療效高于對照組(OR=3?83,95%CI=1?90~7?70,P<0?0002);治療後,觀察組患者胃液pH值高于對照組(MD=1?96,95%CI=1?89~2?04,P<0?00001);觀察組患者平均止血時間短于對照組(MD=1?95,95%CI=1?87~2?03,P<0?00001);納入的文獻均描述2組參與者未見不良反應。結論:質子泵抑製劑在治療應激性潰瘍方麵有良好的療效和安全性,值得推廣應用。
목적:계통평개질자빙억제제치료응격성궤양료효여안전성,이기위림상응용제공경우화적방안。방법:용계산궤검색중국학술기간전문수거고( CNKI)、만방중문기간전문수거고( WanFang Data)、중경유보중문기간전문수거고( VIP),검색시간위1998—2013년。공검색출192개수궤대조시험( randomized controlled trial,RCT),배제불부합적문헌후,사용RevMan 5?0연건진행회췌분석(Meta분석)。결과:공납입8개RCT、637례응격성궤양환자。관찰조지혈료효고우대조조(OR=3?83,95%CI=1?90~7?70,P<0?0002);치료후,관찰조환자위액pH치고우대조조(MD=1?96,95%CI=1?89~2?04,P<0?00001);관찰조환자평균지혈시간단우대조조(MD=1?95,95%CI=1?87~2?03,P<0?00001);납입적문헌균묘술2조삼여자미견불량반응。결론:질자빙억제제재치료응격성궤양방면유량호적료효화안전성,치득추엄응용。
OBJECTIVE:To evaluate the efficacy and safety of proton pump inhibitor( PPI) for stress ulcer so as to provide optimal scheme in its clinical application. METHED: The pertinent data between 1998 to 2013 were electronically retrieved from the databases including CNK, WanFang Data and Vip. A total of 192 randomized controlled trials( RCTs) were retrieved, with ineligible RCTs excluded. Meta?analysis was performed on the eligible RCTs using RevMan 5?0 software. RESULTS:A total of eight RCTs involving 637 cases of stress ulcer were included in our study. The meta?analysis showed that the treatment group was significantly superior to control group in hemostatic efficacy(OR =3?83,95%CI=1?90?7?70,P <0?000 2); the pH value of gastric juice in the treatment group was higher than in the control group(MD=1?96,95%CI=1?89?2?04,P<0?000 01)and the mean hemostatic time in the treatment group was shorter than in the control group(MD=1?95,95%CI=1?87?2?03,P<0?000 01). Adverse drug reactions were noted in neither group. CONCLUSIONS: Treatment of patients with stress ulcer using proton pump inhibitors achieved remarkable efficacy, which thus is worthy of clinical recommendation.