CAJ | 학술논문

目的：分析乌司他丁对体外循环瓣膜置换术患者围手术期炎性因子水平的影响。方法：选取接受体外循环瓣膜置换术治疗的患者92例，并随机分为观察组和对照组，每组46例；分别采用接受乌司他丁治疗和接受等容量生理盐水治疗的方法，检测手术过程中两组患者的炎性因子水平及肺换气功能差异。结果：①于体外循环(CPB)开始后1 h、结束后1 h观察组患者的肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)以及肺泡气-动脉血氧分压差(A-aDO2)水平均低于对照组(t=2.948，t=2.537，t=4.382，t=5.281；P＜0.05)；②两组患者的A-aDO2水平与TNF-α、IL-6水平呈正相关关系(r2=0.567，r2=0.531；P＜0.05)。结论：乌司他丁可以有效降低体外循环瓣膜置换术患者围手术期的炎性因子水平，减少对肺换气功能的影响，且炎性因子水平与A-aDO2水平呈正相关。
목적：분석오사타정대체외순배판막치환술환자위수술기염성인자수평적영향。방법：선취접수체외순배판막치환술치료적환자92례，병수궤분위관찰조화대조조，매조46례；분별채용접수오사타정치료화접수등용량생리염수치료적방법，검측수술과정중량조환자적염성인자수평급폐환기공능차이。결과：①우체외순배(CPB)개시후1 h、결속후1 h관찰조환자적종류배사인자α(TNF-α)、백세포개소-6(IL-6)이급폐포기-동맥혈양분압차(A-aDO2)수평균저우대조조(t=2.948，t=2.537，t=4.382，t=5.281；P＜0.05)；②량조환자적A-aDO2수평여TNF-α、IL-6수평정정상관관계(r2=0.567，r2=0.531；P＜0.05)。결론：오사타정가이유효강저체외순배판막치환술환자위수술기적염성인자수평，감소대폐환기공능적영향，차염성인자수평여A-aDO2수평정정상관。
Objective: To analyze effect of ulinastatin on patients’ inflammatory factors level during cardiopulmonary bypass valve replacement surgery. Methods: Chosen patients accept cardiopulmonary bypass valve replacement surgery between 2011 to 2013 as research subjects, randomized to receive Ulinastatin as observation group and volume of saline as control group, testing inflammatory levels and pulmonary ventilation function difference. Results: One hour after CPB and 1h after the end of CPB, TNF-α, IL-6 level as well as A-aDO2 level of observation group were lower than control group; (2)A-aDO2 levels were positively correlated with TNF-α, IL-6 levels. Conclusion: Ulinastatin can effectively reduce cardiopulmonary bypass valve replacement surgery preoperative inflammatory cytokine levels, reducing the impact on pulmonary ventilation function, inflammatory levels and pulmonary ventilation function was negatively correlated.