CAJ | 학술논문

目的：探讨丹红注射液对急性脑梗死(ACI)患者血清S100B蛋白和神经元特异性烯醇化酶(NSE)水平的影响及临床疗效。方法 ACI患者80例,随机分为治疗组及对照组,每组40例。对照组根据《中国急性缺血性脑卒中诊治指南》给予常规治疗,治疗组另加丹红注射液,治疗14 d。在起病1,3,5,10 d时测定血清S100B蛋白和NSE水平的变化,每例患者在起病1,21 d时分别行美国国立卫生研究院卒中量表( NIHSS)评分。结果治疗组在3,5 d时S100B及NSE水平明显低于对照组(P<0.01),21 d时两组NIHSS评分较治疗前均明显减少,治疗组评分低于对照组(P<0.05)。治疗组及对照组血清S100B蛋白峰值浓度与脑梗死后1 d时NIHSS评分均呈正相关(分别r=0.761,r=0.792,均P<0.01),两组血清NSE水平与脑梗死后1 d时NIHSS评分均呈正相关(分别r=0.734,r=0.756,均P<0.01)。结论丹红注射液能降低急性脑梗死患者血清S100B 及NES 水平,促进神经功能恢复。
목적：탐토단홍주사액대급성뇌경사(ACI)환자혈청S100B단백화신경원특이성희순화매(NSE)수평적영향급림상료효。방법 ACI환자80례,수궤분위치료조급대조조,매조40례。대조조근거《중국급성결혈성뇌졸중진치지남》급여상규치료,치료조령가단홍주사액,치료14 d。재기병1,3,5,10 d시측정혈청S100B단백화NSE수평적변화,매례환자재기병1,21 d시분별행미국국립위생연구원졸중량표( NIHSS)평분。결과치료조재3,5 d시S100B급NSE수평명현저우대조조(P<0.01),21 d시량조NIHSS평분교치료전균명현감소,치료조평분저우대조조(P<0.05)。치료조급대조조혈청S100B단백봉치농도여뇌경사후1 d시NIHSS평분균정정상관(분별r=0.761,r=0.792,균P<0.01),량조혈청NSE수평여뇌경사후1 d시NIHSS평분균정정상관(분별r=0.734,r=0.756,균P<0.01)。결론단홍주사액능강저급성뇌경사환자혈청S100B 급NES 수평,촉진신경공능회복。
Objective To obserVe influence of danhong injection on leVels of serum S100B Protein and neuron_sPecific enolase ( NSE) in Patients with acute cerebral infarction ( ACI) ,and to exPlore its clinical effect. Methods Eighty cases of ACI were randomly diVided into treatment grouP and control grouP with 40 cases in each grouP. Both grouPs were giVen routine treatment according to the clinical guideline. Treatment grouP receiVed danhong injection once a day for 14 days. LeVels of serum S100B Protein and NSE were detected 1,3,5 and 10 days after ACI. The Patients in the two grouPs were eValuated by NIHSS 1 and 21 day(s) after ACI. Results ComPared with control grouP,leVels of serum S100B Protein and NSE were significantly lower in treatment grouP than in control grouP 3 and 5 days after ACI (all P<0. 01). NIHSS scores were significantly decreased 21 days after ACI in both grouPs,and NIHSS scores were lower in treatment grouP than in control grouP (P<0. 05). Peak concentration of S100B Protein in treatment grouP and control grouP was PositiVely correlated with NIHSS scores ( r=0. 761 and r=0. 792,resPectiVely,both P<0. 01). Conclusion Danhong injection can decrease serum S100B and NSE leVels,and imProVe the neurological function in ACI Patients.