CAJ | 학술논문

目的：观察一清胶囊治疗并发便秘的痤疮患者的临床疗效与安全性。方法采用随机对照的方法将145例并发便秘的痤疮患者分为治疗组和对照组，治疗组(75例)予一清胶囊口服联合外用复方维A酸凝胶，对照组(70例)单外用复方维A酸凝胶作对照，均治疗3周。结果治疗组痤疮的疗效明显优于对照组(P<0.01)，两组均未出现明显不良反应。治疗组77.4%患者便秘症状明显改善，高于对照组(P<0.01)，治疗组和对照组中便秘改善者痤疮的治疗效果均明显优于便秘未改善者(P<0.01)，痤疮疗效与便秘改善情况的SPearman相关系数为0.699(P<0.01)。结论一清胶囊联合复方维A酸凝胶治疗痤疮疗效肯定，无明显不良反应，改善便秘进而明显提高对痤疮的疗效。
목적：관찰일청효낭치료병발편비적좌창환자적림상료효여안전성。방법채용수궤대조적방법장145례병발편비적좌창환자분위치료조화대조조，치료조(75례)여일청효낭구복연합외용복방유A산응효，대조조(70례)단외용복방유A산응효작대조，균치료3주。결과치료조좌창적료효명현우우대조조(P<0.01)，량조균미출현명현불량반응。치료조77.4%환자편비증상명현개선，고우대조조(P<0.01)，치료조화대조조중편비개선자좌창적치료효과균명현우우편비미개선자(P<0.01)，좌창료효여편비개선정황적SPearman상관계수위0.699(P<0.01)。결론일청효낭연합복방유A산응효치료좌창료효긍정，무명현불량반응，개선편비진이명현제고대좌창적료효。
Objective To obserVe the clinical efficacy and safety of yiqing caPsule in the treatment of acne with concomitant constiPation. Methods A randomized controlled method was used. One hundred and forty_fiVe Patients with acne and concomitant constiPation were randomized into treatment grouP (n=75) and control grouP (n=70). Patients in the treatment grouP receiVed yiqing caPsule orally and comPound tretinoin gel toPically, while Patients in the control grouP receiVed toPical comPound tretinoin gel only. Both grouPs were treated for 3 weeks. Results The theraPeutic effect of the treatment grouP was much better than that of control grouP (P<0. 01). No obVious adVerse reactions were obserVed in either grouP. In the treatment grouP,77.4%of Patients were relieVed from constiPation,the ratio being much higher than the control grouP (P<0.01). The chance of acne relief was remarkably higher in Patients whose constiPation were relieVed (P<0. 01). The SPearman correlation index between acne relief and constiPation imProVement was 0. 699 (P<0. 01). Conclusion Combination theraPy of yiqing caPsule and comPound tretinoin gel is effectiVe in the treatment of acne with no significant adVerse reactions. The constiPation imProVement from yiqing caPsule can contribute to the efficacy towards acne.