CAJ | 학술논문

目的：观察蛇床子素对脑缺血_再灌注损伤大鼠的保护作用。方法采用线栓法制备局灶性脑缺血_再灌注模型，在脑缺血2 h再灌注24 h后，对大鼠神经功能进行评分，并测定脑梗死体积；同时测定脑组织匀浆中超氧化物歧化酶( SOD)、丙二醛( MDA)、还原型谷胱甘肽( GSH)及线粒体中ATP酶的含量。结果与模型对照组比较，蛇床子素能降低脑梗死体积、改善脑缺血_再灌注大鼠神经功能，升高SOD活性、增加GSH含量，同时降低MDA含量。结论蛇床子素对大鼠脑缺血_再灌注损伤有保护作用。
목적：관찰사상자소대뇌결혈_재관주손상대서적보호작용。방법채용선전법제비국조성뇌결혈_재관주모형，재뇌결혈2 h재관주24 h후，대대서신경공능진행평분，병측정뇌경사체적；동시측정뇌조직균장중초양화물기화매( SOD)、병이철( MDA)、환원형곡광감태( GSH)급선립체중ATP매적함량。결과여모형대조조비교，사상자소능강저뇌경사체적、개선뇌결혈_재관주대서신경공능，승고SOD활성、증가GSH함량，동시강저MDA함량。결론사상자소대대서뇌결혈_재관주손상유보호작용。
Objective To inVestigate the Potential mechanism and ProtectiVe effects of osthole on rats with focal cerebral ischemia_rePerfusion injury. Methods Middle cerebral artery occlusion was induced by the suture_occluded method. After 2 h of cerebral ischemia and 24 h of rePerfusion,scores of neurological deficits and infarct Volume were eValuated. The leVels of SOD,MDA,GSH and ATPase were also determined. Results Scores of neurological deficits and infarct Volume were lower in the osthole grouPs than in the model grouP. Meanwhile,the actiVity of SOD and GSH content were increased,while the MDA content was decreased in osthole grouPs. Conclusion Osthole exerts ProtectiVe effects on rats with focal cerebral ischemia_rePerfusion injury.