CAJ | 학술논문

目的：观察奥曲肽保守治疗直肠癌术后早期炎症性肠梗阻患者的临床疗效。方法选取2013年4月至2014年4月行保守治疗的直肠癌根治术后早期炎症性肠梗阻患者80例，随机分为治疗组和对照组，各40例。对照组进行禁食禁饮、持续胃肠减压、静脉营养支持、纠正酸碱平衡紊乱以及抗感染等常规治疗，治疗组在对照组治疗基础上加用奥曲肽，观察并记录两组患者的临床疗效、症状缓解状况、治疗前后胃肠减压引流量以及不良反应。结果治疗组总有效率为85.00%，明显高于对照组的55.00%（ P＜0.05）。治疗组患者腹痛腹胀缓解时间以及肛门排气排便时间均低于对照组，胃肠减压引流量明显比对照组少（ P＜0.05）；两组患者不良反应主要是电解质紊乱以及白细胞异常，不良反应发生率组间比较无明显差异（ P>0.05）。结论奥曲肽用于术后早期炎性肠梗阻的保守治疗临床疗效好，且不良反应并无增加，值得临床推广。
목적：관찰오곡태보수치료직장암술후조기염증성장경조환자적림상료효。방법선취2013년4월지2014년4월행보수치료적직장암근치술후조기염증성장경조환자80례，수궤분위치료조화대조조，각40례。대조조진행금식금음、지속위장감압、정맥영양지지、규정산감평형문란이급항감염등상규치료，치료조재대조조치료기출상가용오곡태，관찰병기록량조환자적림상료효、증상완해상황、치료전후위장감압인류량이급불량반응。결과치료조총유효솔위85.00%，명현고우대조조적55.00%（ P＜0.05）。치료조환자복통복창완해시간이급항문배기배편시간균저우대조조，위장감압인류량명현비대조조소（ P＜0.05）；량조환자불량반응주요시전해질문란이급백세포이상，불량반응발생솔조간비교무명현차이（ P>0.05）。결론오곡태용우술후조기염성장경조적보수치료림상료효호，차불량반응병무증가，치득림상추엄。
Objective To observe the clinical efficacy of octreotide in the conservative treatment of early inflammatory ileus after col-orectal cancer operation. Methods 80 cases of early inflammatory ileus after the radical operation of colorectal cancer in our hospital from April 2013 to April 2014 were selected and randomly divided into the treatment group and the control group, 40 cases in each group. The control group was given the routine therapy of fasting and water-deprivation, continuous gastrointestinal decompression, intra-venous nutritional support, correcting acid-base balance disorders and anti-infection, while on this basis the treatment group was added with octreotide. The clinical efficacy, symptomatic alleviation condition, drainage volume of gastrointestinal decompression before and after treatment, and adverse reactions were observed and recorded. Results The total effective rate was 85. 00% in the treatment group and 55. 00% in the control group, the difference was statistically significant ( P<0. 05 ) , the relief time of abdominal pain and abdominal dis-tension and the time of anal exhaust and defecation in the treatment group were shorter than those in the control group, the drainage volume of gastrointestinal decompression in the treatment group was significantly less than that in the control group, the difference was statistically significant ( P<0. 05 ); the adverse reactions in the two groups were mainly the electrolyte imbalance and abnormal WBC, comparing the two groups showed no statistical difference in the occurrence of adverse reactions ( P>0. 05 ) . Conclusion Octreotide has better clinical effect without increasing adverse reactions for the conservative treatment of early postoperative inflammatory ileus and is worthy of being promoted in clinic.