CAJ | 학술논문

目的：观察铝碳酸镁片联合埃索美拉唑、莫沙必利治疗胃食管反流病的疗效和安全性。方法将125例胃食管反流病患者随机分为观察组和对照组。观察组63例给予铝碳酸镁片联合埃索美拉唑、莫沙必利治疗，对照组62例给予奥美拉唑联合莫沙必利治疗。结果两组的症状评分和内镜检查评分均有明显下降，但观察组下降更显著（ P＜0.05）。观察组的临床总有效率（96.83%）比对照组（75.81%）高（ P＜0.05）。观察组的内镜下总有效率（95.24%）比对照组的总有效率（80.64%）高（ P＜0.05）。两组的不良反应发生率比较（6.34%比6.45%）无显著性差异（ P>0.05）。结论铝碳酸镁片联合埃索美拉唑、莫沙必利治疗胃食管反流病疗效显著，安全性高，值得临床推广。
목적：관찰려탄산미편연합애색미랍서、막사필리치료위식관반류병적료효화안전성。방법장125례위식관반류병환자수궤분위관찰조화대조조。관찰조63례급여려탄산미편연합애색미랍서、막사필리치료，대조조62례급여오미랍서연합막사필리치료。결과량조적증상평분화내경검사평분균유명현하강，단관찰조하강경현저（ P＜0.05）。관찰조적림상총유효솔（96.83%）비대조조（75.81%）고（ P＜0.05）。관찰조적내경하총유효솔（95.24%）비대조조적총유효솔（80.64%）고（ P＜0.05）。량조적불량반응발생솔비교（6.34%비6.45%）무현저성차이（ P>0.05）。결론려탄산미편연합애색미랍서、막사필리치료위식관반류병료효현저，안전성고，치득림상추엄。
Objective To investigate the clinical efficacy and safety of Hydrotalcite Tablet combined with esomeprazole and mosapride in the treatment of gastroesophageal reflux disease. Methods 125 patients with gastroesophageal reflux disease were randomly divided into the observation group and the control group. 63 cases in the observation group were given the therapy of Hydrotalcite Tablets combined with esomeprazole and mosapride, while 62 cases in the control group were given the therapy of omeprazole combined with mosapridel. The clinical efficacy and safety were compared between the two groups. Results The symptom scores and the endoscopic examination scores after treatment in the two groups were significantly decreased, but the decrease in the observation group was more significant. From the aspect of the clinical curative effect, the total effective rate in the observation group was 96. 83%, which was high-er than 75. 81% in the control group, the difference between the two groups had statistical significance ( P<0. 05 ) . From the aspect of the endoscopic curative effect, the total effective rate in the observation group was 95. 24%, which was higher than 80. 64% in the control group, the difference between the two groups had statistical significance ( P<0. 05 ) . The occurrence rate of adverse reactions had no statistical difference between two groups ( 6. 34% vs. 6. 45%, P>0. 05 ) . Conclusion Hydrotalcite Tablet combined with esomeprazole and mosapride is significantly effective and safe in the treatment of gastroesophageal reflux disease and deserves to be promoted in clinic.