CAJ | 학술논문

目的：考察注射用硝普钠（SNP）与5%葡萄糖注射液（5%GS）配伍的稳定性。方法根据临床应用配制SNP溶液，考察在不同环境和不同放置时间下SNP溶液的稳定性，包括溶液性状、pH、不溶微粒、紫外－可见吸收光谱和SNP含量等。结果避光套避光，在20℃或35℃时，SNP与5%GS混合后26 h内稳定；不避光时，任何条件下溶液均不稳定，溶液的稳定性与浓度无关，与光照和强度与时间密切相关。结论在避光条件下，SNP与5%GS配伍26 h内稳定。
목적：고찰주사용초보납（SNP）여5%포도당주사액（5%GS）배오적은정성。방법근거림상응용배제SNP용액，고찰재불동배경화불동방치시간하SNP용액적은정성，포괄용액성상、pH、불용미립、자외－가견흡수광보화SNP함량등。결과피광투피광，재20℃혹35℃시，SNP여5%GS혼합후26 h내은정；불피광시，임하조건하용액균불은정，용액적은정성여농도무관，여광조화강도여시간밀절상관。결론재피광조건하，SNP여5%GS배오26 h내은정。
Objective To investigate the compatible stability of Nitroprusside Sodium for Injection ( SNP ) and 5% Glucose Injection ( 5%GS ) . Methods SNP and 5%GS were prepared into the compatible solution according to clinical demand. The stability of SNP compati-ble solution was investigated in different environments and different storage time, including the solution character, appearance, pH value, insoluble particle, ultraviolet-visible absorption and SNP content. Results The compatible solution of SNP mixed with 5% GS was sta-ble within 26 h keeping in dark place by lucifugal cover at 20℃ or 35℃. Under the any condition without keeping in dark place, the solution was unstable. The solution stability had no relation with the concentration and was closely correlated with the illumination in-tensity and time. Conclusion In the dark condition, the compatible solution of SNP and 5% GS is stable within 26 h.