CAJ | 학술논문

目的：考察益精灵口服液长期给药对大鼠的影响，为临床安全用药提供科学参考依据。方法将大鼠随机分为对照组及低[0.5 mL/(kg·d)]、中[2.5 mL/(kg·d)]、高[5 mL/(kg·d）]剂量组，给药量分别相当于临床患者每日用量的1，5，10倍。30 d后每组随机处死雌雄大鼠各5只，取尾静脉血进行血常规检查和血液生化指标，以及心、肝、肾、肺作组织病理学检查。结果连续给药30 d后，各剂量组动物的体重、血液生化指标、血常规未发生变化，心、肝、肾、肺均未见有明显的病理改变。结论益精灵口服液临床用药较安全。
목적：고찰익정령구복액장기급약대대서적영향，위림상안전용약제공과학삼고의거。방법장대서수궤분위대조조급저[0.5 mL/(kg·d)]、중[2.5 mL/(kg·d)]、고[5 mL/(kg·d）]제량조，급약량분별상당우림상환자매일용량적1，5，10배。30 d후매조수궤처사자웅대서각5지，취미정맥혈진행혈상규검사화혈액생화지표，이급심、간、신、폐작조직병이학검사。결과련속급약30 d후，각제량조동물적체중、혈액생화지표、혈상규미발생변화，심、간、신、폐균미견유명현적병리개변。결론익정령구복액림상용약교안전。
Objective To investigate the influence of long term administration of Yijinging Oral Liquid on rats so as to provide the scientific basis for its clinical safe use. Methods Rats were divided into four groups and administrated by oral saline, 0. 5 mL/(kg·d), 2. 5 mL/ (kg·d), 5 mL/ (kg·d) of Yijingling Oral Liquid respectively, which equivalent to 1, 5, 10 times of daily dose in clinical patients. All the rates were executed after 30 d, and the blood routine examination ( Hb, WBC, RBC ) , blood biochemical index ( AST, ALT, T-BIL ) and histopathological examination ( heart, liver, lung and kidney ) were performed. Results After 30 d,No changes were found neither in the body weight, blood routine examination and blood biochemical index, nor in the histopathological examination of heart, kidney and liver in the various doses groups. Conclusion Yijingling Oral Liquid can be safely used in clinic.