CAJ | 학술논문

目的：探讨人骨肉瘤组织和邻近正常骨组织中miR-17-92基因簇的表达情况及其临床意义。方法：运用Q-PCR法检测63例骨肉瘤组织及邻近部位正常骨组织中miR-17-92基因簇的表达水平，并分析miR-17-92基因簇表达与患者临床病理特征及预后的关系。结果：miR-17-92在所有组织中均有表达，且在肿瘤组织中表达明显高于在正常组织中的表达（P<0.05），另外， miR-17-92基因簇高表达患者预后更差，差异有统计学意义（P=0.027）。结论：miR-17-92基因簇在骨肉瘤组织和邻近正常骨组织中表达存在差异性，可能在骨肉瘤发生、发展过程中起重要作用，有望成为骨肉瘤患者预后一种新的指标。
목적：탐토인골육류조직화린근정상골조직중miR-17-92기인족적표체정황급기림상의의。방법：운용Q-PCR법검측63례골육류조직급린근부위정상골조직중miR-17-92기인족적표체수평，병분석miR-17-92기인족표체여환자림상병리특정급예후적관계。결과：miR-17-92재소유조직중균유표체，차재종류조직중표체명현고우재정상조직중적표체（P<0.05），령외， miR-17-92기인족고표체환자예후경차，차이유통계학의의（P=0.027）。결론：miR-17-92기인족재골육류조직화린근정상골조직중표체존재차이성，가능재골육류발생、발전과정중기중요작용，유망성위골육류환자예후일충신적지표。
Objective:To determine the expression of miR-17-92 cluster in osteosarcoma tissue samples and explore its associa-tion with clinical significance. Methods: Quantitative polymerase chain reactiom analysis was used to examine the expression of miR-17-92 cluster in osteosarcoma tissues. Normal bone tissues from 63 patients were matched, and the relationships between the ex-pression of miR-17-92 cluster and the clinicopathological features and prognosis of osteosarcoma were explored. Results:The relative expression of miR-17-92 cluster in osteosarcoma tissues was significantly higher than those in adjacent normal tissues (P<0.05). The high expression of miR-17-92 had a significant correlation with reduced survival (P=0.027). Conclusion:The expression of miR-17-92 cluster closely correlates with the occurrence and progress of osteosarcoma and may be used as an indicator for osteosarcoma prognosis.