CAJ | 학술논문

目的：观察高强度聚焦超声消融兔腹主动脉旁肝肿瘤后肝肿瘤剂量学、磁共振图像、病理学及生存期影响，评价HIFU消融兔腹主动脉旁肝肿瘤安全性和有效性。方法：分别于HIFU组（32只）和对照组（20只）实验兔建立腹主动脉旁的VX2肝肿瘤模型，HIFU组瘤兔于MR引导的高强度聚焦超声消融肿瘤，分析腹主动脉旁肿瘤消融剂量学，MR观察消融前后肿瘤影像学变化，病理学观察肿瘤消融后坏死情况，对比观察HIFU组与对照组瘤兔生存期。结果：MRI和病理学均表明MR引导下HIFU能完全消融兔腹主动脉旁VX2肝肿瘤，EEF为25.72±11.40 J/mm3 HIFU组的生存期明显高于对照组，差异具有统计学意义（P<0.05）。结论：HIFU能安全有效消融兔腹主动脉旁VX2肝肿瘤并且能明显提高存活期。
목적：관찰고강도취초초성소융토복주동맥방간종류후간종류제량학、자공진도상、병이학급생존기영향，평개HIFU소융토복주동맥방간종류안전성화유효성。방법：분별우HIFU조（32지）화대조조（20지）실험토건립복주동맥방적VX2간종류모형，HIFU조류토우MR인도적고강도취초초성소융종류，분석복주동맥방종류소융제량학，MR관찰소융전후종류영상학변화，병이학관찰종류소융후배사정황，대비관찰HIFU조여대조조류토생존기。결과：MRI화병이학균표명MR인도하HIFU능완전소융토복주동맥방VX2간종류，EEF위25.72±11.40 J/mm3 HIFU조적생존기명현고우대조조，차이구유통계학의의（P<0.05）。결론：HIFU능안전유효소융토복주동맥방VX2간종류병차능명현제고존활기。
Objective:To evaluate the safety and efficacy of high-intensity focused ultrasound (HIFU) ablation for the VX2 liver tumor near the hepatic main blood vessels of rabbits by using dosimetry and magnetic resonance imaging (MRI) and by analyzing path-ological changes and survival. Methods:Rabbits with VX2 liver tumor adjacent to the abdominal aorta were divided into the HIFU (n=32) and control groups (n=20). MRI-guided HIFU was employed for the ablation of the liver tumor in the HIFU group. The ablation vol-ume and the energy efficiency factor (EEF) of the 32 ablated rabbits were further analyzed. MRI and pathology were used to compare the changes in the tumor before and after HIFU. The survival of the animals in the HIFU and control groups was also determined. Re-sults: Both pathology and imaging showed that the rabbit liver VX2 tumor adjacent to the abdominal aorta was completely ablated, with an EEF of (25.72±11.40) J/mm3. The survival rate was significantly higher in the HIFU group than in the control group (P<0.05). Conclusion: HIFU ablation is safe and effective in rabbit VX2 liver tumor near the abdominal aorta. This approach significantly in-creases survival.