CAJ | 학술논문

目的：观察丹酚酸联合氨氯地平对高血压合并高脂血症大鼠的治疗作用。方法24只自发性高血压大鼠，高脂饲喂2周后，随机分成氨氯地平组、多达一（苯磺酸氨氯地平阿托伐他汀钙片）组、联合用药组和对照组4组，每组6只。连续给药4周，并继续饲喂高脂，测定大鼠给药前后的血压、血脂，血浆、肝和心肌组织中超氧化物歧化酶（SOD）和丙二醛（MDA）含量。结果治疗4周后，对照组血压升高，HDL- C降低（P＜0.05和0.01）；联合用药组血压、血TG、LDL- C、LDL- C /HDL- C、肝组织TC和TG水平，血浆和心肌组织MDA降低，SOD活性和SOD /MDA比值升高，与对照组比较差异有统计学意义（P＜0.05或0.01）；氨氯地平组和多达一组血压、LDL- C、LDL- C /HDL- C、肝组织TC水平、心肌组织MDA含量降低，心肌组织SOD/MDA比值升高，与对照组比较差异有统计学意义（P＜0.05或0.01），多达一组肝组织TG低于对照组，差异有统计学意义（P＜0.05）。结论丹酚酸联合氨氯地平能协同增强高血压合并高脂血症大鼠的降压和降脂作用，其作用与抑制脂质过氧化、保护血管内皮功能有关。
목적：관찰단분산연합안록지평대고혈압합병고지혈증대서적치료작용。방법24지자발성고혈압대서，고지사위2주후，수궤분성안록지평조、다체일（분광산안록지평아탁벌타정개편）조、연합용약조화대조조4조，매조6지。련속급약4주，병계속사위고지，측정대서급약전후적혈압、혈지，혈장、간화심기조직중초양화물기화매（SOD）화병이철（MDA）함량。결과치료4주후，대조조혈압승고，HDL- C강저（P＜0.05화0.01）；연합용약조혈압、혈TG、LDL- C、LDL- C /HDL- C、간조직TC화TG수평，혈장화심기조직MDA강저，SOD활성화SOD /MDA비치승고，여대조조비교차이유통계학의의（P＜0.05혹0.01）；안록지평조화다체일조혈압、LDL- C、LDL- C /HDL- C、간조직TC수평、심기조직MDA함량강저，심기조직SOD/MDA비치승고，여대조조비교차이유통계학의의（P＜0.05혹0.01），다체일조간조직TG저우대조조，차이유통계학의의（P＜0.05）。결론단분산연합안록지평능협동증강고혈압합병고지혈증대서적강압화강지작용，기작용여억제지질과양화、보호혈관내피공능유관。
Objective To observe therapy effect of Salvianolic acid (SA) combined with amlodipine on rats with hypertension and hyperlipidemia. Methods 24 spontaneously hypertensive rats (SHR) fed high- fat diet for 2 weeks and then randomly fed amlodipine (AMl group, n=6), amlodipine plus atorvastatin (AMLAT group, n=6), SA plus amlodipine (SAAML group, n=6) or water (control group, n=6), respectively, as well as high- fat diet for 4 weeks. Blood pressure, serum lipids, superoxide dismutase (SOD) and malondialdehyde (MDA) of plasma, liver and myocardium were measured before and after treatment. Results After 4 weeks treatment, blood pressure increased and HDL- C decreased significantly in control group(P<0.05or0.01). Serum TG, LDL- C, LDL- C/HDL- C, hepatic TC and TG decreased, plasma and myocardial MDA decreased, SOD and ratio of SOD/MDA increased significantly in SAAML group compared to control group ( al P<0.05 or 0.01). Blood pressure, LDL- C, LDL- C /HDL- C, hepatic TC, myocardial MDA decreased, myocardial SOD/MDA increased significantly in AML and AMLAT groups compared to control group(P<0.05 or 0.01). Hepatic TG was significantly lower in AMLAT group than control group (P<0.05). Conclusion Salvianolic acid combined with amlodipine may have synergetic effects on blood pressure and lipid lowering in SHR with hyperlipidemia. The possible mechanisms are related to inhibition of lipid peroxidation and protection of endothelial function.