CAJ | 학술논문

试验用重楼薯蓣皂苷（SY）和偏诺皂苷（PN ）对微囊藻毒素浸染的小鼠进行连续灌胃，并通过对小鼠肝脏进行石蜡包埋、制片和HE染色，观察小鼠肝组织的显微结构，目的在于研究重楼皂苷类化合物对微囊藻毒素（MC）所致肝损伤的保护作用。结果显示，微囊藻毒素具有肝毒性，致肝小叶结构严重破坏，而重楼薯蓣皂苷和偏诺皂苷对微囊藻毒素所致的肝损伤均有保护作用。
시험용중루서여조감（SY）화편낙조감（PN ）대미낭조독소침염적소서진행련속관위，병통과대소서간장진행석사포매、제편화HE염색，관찰소서간조직적현미결구，목적재우연구중루조감류화합물대미낭조독소（MC）소치간손상적보호작용。결과현시，미낭조독소구유간독성，치간소협결구엄중파배，이중루서여조감화편낙조감대미낭조독소소치적간손상균유보호작용。
Mouse induced by microcystin was chronically intragastric lavement by dioscins and pennogenyl saponins.The liver of the mouse was embeded in paraffin and made slice for HE staining to observe the liver tissue micro structure of the mouse and the purpose is to study whether the saponins in Rhizoma Paridis Yunnanensis prevent liver from damage induced by microcystin.The results showed that microcystin is hepatotoxic and induce serious collapse of lobular architecture;but both dioscins and pennogenyl saponins can protect liver from damage induced by microcystin.