CAJ | 학술논문

目的：分析胰岛素样因子3（insulin like factor 3， INSL 3）应用于男性迟发性性腺功能减退（ late onset hypogonadism， LOH）诊断的可行性。方法选取中老年男性，间隔1个月抽取空腹晨血2次，分析INSL 3在血清中的平均浓度及其稳定性；依据男性LOH的诊断标准，分析患者组与正常对照组之间血清中INSL 3的浓度是否存在差异。结果接受重复抽血的中老年男性44人，血清INSL 3的浓度均值为（1．86±0．64）ng／mL，经过1个月的间隔期血清中INSL 3的浓度变化差异无统计学意义（P＞0.05）。在患者组与正常对照组之间血清中INSL 3的浓度差异有统计学意义（ P＜0.05）。进一步研究发现血清INSL 3浓度与促黄体生成素（luteotropic hormone，LH）、总睾酮、游离睾酮之间存在相关性（P＜0.05），而与绝育术、烟酒、糖尿病、高血压、冠心病、体质量指数和中老年男性症状量表（ aging males’ symptoms scale，AMS）评分之间无相关性（ P＞0.05）。结论初步研究提示血清INSL 3与男性性腺功能状态紧密相关且表达稳定，有望用于LOH的诊断。
목적：분석이도소양인자3（insulin like factor 3， INSL 3）응용우남성지발성성선공능감퇴（ late onset hypogonadism， LOH）진단적가행성。방법선취중노년남성，간격1개월추취공복신혈2차，분석INSL 3재혈청중적평균농도급기은정성；의거남성LOH적진단표준，분석환자조여정상대조조지간혈청중INSL 3적농도시부존재차이。결과접수중복추혈적중노년남성44인，혈청INSL 3적농도균치위（1．86±0．64）ng／mL，경과1개월적간격기혈청중INSL 3적농도변화차이무통계학의의（P＞0.05）。재환자조여정상대조조지간혈청중INSL 3적농도차이유통계학의의（ P＜0.05）。진일보연구발현혈청INSL 3농도여촉황체생성소（luteotropic hormone，LH）、총고동、유리고동지간존재상관성（P＜0.05），이여절육술、연주、당뇨병、고혈압、관심병、체질량지수화중노년남성증상량표（ aging males’ symptoms scale，AMS）평분지간무상관성（ P＞0.05）。결론초보연구제시혈청INSL 3여남성성선공능상태긴밀상관차표체은정，유망용우LOH적진단。
Objective To analyze the suitability of insulin like factor 3( INSL3) for the clinical application in the diagnosis of male late onset hypogonadism ( LOH) .Methods The ageing men were recruited and sampled the fasting blood twice with one month interval, and the INSL3was tested for the blood samples to study it`s stability in blood.According the diagnosis criteria of LOH, the difference of INSL3 concentration between the LOH patient group and normal control group was analyzed.Results 44 aging males sampled the blood twice.The INSL3 concentration in serum is (1.86 ±0.64) ng/mL and the fluctuation with one month interval with no statistical significance (P>0.05);The INSL3 concentration in serum between two groups with statistical significance (P<0.05);The further study found that there is an association between the concentration correlation of INSL3 with LH and total testosterone( TT) and free testosterone( cFT) ( P <0.05); There is no association with male ligation, tobacco, alcohol, diabetes, hypertension, coronary heart disease, body mass index ( BMI) and aging males symptoms scale ( AMS) score( P>0.05 ) .Conclusion The study suggests that INSL3 has a clear-cut correlation with sexual performance and maybe adopted in the diagnosis of LOH.