不同年龄段男性血清总睾酮和游离睾酮水平分析
불동년령단남성혈청총고동화유리고동수평분석
Analysis of male serum total Testosterone and serum free Testosterone in different ages
  • 万方数据
    中国计划生育和妇产科 중국계화생육화부산과
    CHINESE JOURNAL OF FAMILY PLANNING & GYNECOTOKOLOGY
    2014年 9期 16-18 ,共3页

    刘太华%杨瑞峰%孔祥斌%陈耀平%李红钢%章慧平%夏伟%官黄涛%谷翊群%商学军%周远忠%吴伟雄%熊承良

    류태화%양서봉%공상빈%진요평%리홍강%장혜평%하위%관황도%곡익군%상학군%주원충%오위웅%웅승량

    睾酮%游离睾酮%性激素结合球蛋白 睪酮%遊離睪酮%性激素結閤毬蛋白
    고동%유리고동%성격소결합구단백
    serum total testosterone%serum free testosterone%sex hormone binding globulin
    了解不同年龄段男性血清总睾酮（ total testosterone， TT ）和游离睾酮（ calculated free testosterone， cFT）水平的变化。方法按不同年龄段将研究对象分为6个组。分别测定血清TT、性激素结合球蛋白（ sex hormone binding globulin， SHBG），计算出血清cFT，分析年龄与男性血清TT和cFT水平的关系。结果不同年龄组间血清TT水平60～＜70岁组与30～＜40岁、40～＜50岁组比较差异有统计学意义（ P＜0.05），其他各组间差异无统计学意义（P＞0.05）。血清cFT、SHBG水平除20～＜30岁、30～＜40岁两组间比较差异无统计学意义（P＞0.05），其他各组间两两比较差异均有统计学意义（P＜0.05）。血清TT，SHBG与年龄呈正相关，而血清cFT与年龄呈负相关（P＜0.05）。结论随着年龄的增长，血清TT水平呈现微弱升高趋势，而血清cFT水平在40岁以后出现明显下降。作为中老年男性性腺功能低下诊断指标，血清cFT水平具有更好的敏感性。
    료해불동년령단남성혈청총고동（ total testosterone， TT ）화유리고동（ calculated free testosterone， cFT）수평적변화。방법안불동년령단장연구대상분위6개조。분별측정혈청TT、성격소결합구단백（ sex hormone binding globulin， SHBG），계산출혈청cFT，분석년령여남성혈청TT화cFT수평적관계。결과불동년령조간혈청TT수평60～＜70세조여30～＜40세、40～＜50세조비교차이유통계학의의（ P＜0.05），기타각조간차이무통계학의의（P＞0.05）。혈청cFT、SHBG수평제20～＜30세、30～＜40세량조간비교차이무통계학의의（P＞0.05），기타각조간량량비교차이균유통계학의의（P＜0.05）。혈청TT，SHBG여년령정정상관，이혈청cFT여년령정부상관（P＜0.05）。결론수착년령적증장，혈청TT수평정현미약승고추세，이혈청cFT수평재40세이후출현명현하강。작위중노년남성성선공능저하진단지표，혈청cFT수평구유경호적민감성。
    Objective To explore the variation of serum total testosterone ( TT) and calculated serum free testosterone ( cFT) in male of different ages.Methods The subjects were divided into six groups according to age groups.The level of TT and sex hormone binding globulin ( SHBG) were detected.Then serum cFT was calculated.The relationship between levels of serum TT, cFT and age were analyzed.Results The differences in level of TT between 60~<70 group and 30~<40 group, 40~<50 group had statistical significance (P<0.05), no significant differences between other groups were found (P>0.05).The differences in level of cFT,&nbsp;SHBG between 20~<30 group and 30~<40 group had no statistical significance(P>0.05).The differences between other groups had statistical significance (P<0.05).TT and SHBG were positively correlated with age while cFT was negatively correlated with age (P<0.05).Conclusion The tendency of the level of TT increases slightly with ages, while the level of cFT has obviously declining trend in an adult >40.As the diagnostic criteria of hypogonadism in the middle-aged and elderly male, the level of cFT has better sensitivity.
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