CAJ | 학술논문

目的：探讨输精管结扎术后对中老年男性性腺功能的远期影响。方法随机抽取有输精管结扎史的167例中老年男性，按照结扎年限不同分成10年组（10～19年）、20年组（20～29年）、30年组（≥30年）。按1∶1匹配未结扎、有生育史的167例中老年男性作为对照组。测量研究对象血清总睾酮（ total testosterone，TT）、游离睾酮（ free testosterone， cFT）、雌二醇（ estradiol， E2）、性激素结合球蛋白（ sex hormone binding globulin， SHBG）、卵泡刺激素（ follicle－stimulating hormone， FSH）、黄体生成素（ luteinizing hormone， LH）水平，简体中文版老年男性症状量表（ CN－AMS）得分，比较两组间及不同结扎年限间的差异。结果结扎组与对照组在血清TT、 cFT、 E2、 SHBG、 FSH 、LH水平及CN－AMS得分比较差异无统计学意义（ P＞0.05）。结扎10年组、20年组与对照组的各指标比较差异无统计学意义（ P＞0.05）；结扎30年组血清cFT明显低于对照组（ P＜0.05），血清TT、E2、SHBG、FSH、LH水平及CN－AMS得分比较差异无统计学意义（ P＞0.05）。结论输精管结扎术后对中老年男性性腺功能远期没有明显影响。
목적：탐토수정관결찰술후대중노년남성성선공능적원기영향。방법수궤추취유수정관결찰사적167례중노년남성，안조결찰년한불동분성10년조（10～19년）、20년조（20～29년）、30년조（≥30년）。안1∶1필배미결찰、유생육사적167례중노년남성작위대조조。측량연구대상혈청총고동（ total testosterone，TT）、유리고동（ free testosterone， cFT）、자이순（ estradiol， E2）、성격소결합구단백（ sex hormone binding globulin， SHBG）、란포자격소（ follicle－stimulating hormone， FSH）、황체생성소（ luteinizing hormone， LH）수평，간체중문판노년남성증상량표（ CN－AMS）득분，비교량조간급불동결찰년한간적차이。결과결찰조여대조조재혈청TT、 cFT、 E2、 SHBG、 FSH 、LH수평급CN－AMS득분비교차이무통계학의의（ P＞0.05）。결찰10년조、20년조여대조조적각지표비교차이무통계학의의（ P＞0.05）；결찰30년조혈청cFT명현저우대조조（ P＜0.05），혈청TT、E2、SHBG、FSH、LH수평급CN－AMS득분비교차이무통계학의의（ P＞0.05）。결론수정관결찰술후대중노년남성성선공능원기몰유명현영향。
Objective To investigate the long-term effects of vasectomy on gonadal function in middle-aged and elderly men . Methods 167 middle-aged and elderly men with a history of vasectomy were randomly chosen, according to the different vasectomy time, cases were divided into 10 years group (10~19 years ) , 20 years group (20~29 years ) , 30 years group (≥30 years ). 167 cases with reproductive history, non-ligation middle-aged and elderly men were selected as a control group.The total serum testosterone (TT), free serum testosterone (cFT), estradiol (E2), sex hormone binding globulin (SHBG), follicle -stimulating hormone (FSH), luteinizing hormone (LH) levels , Chinese version of the aging males’ symptoms scale (CN-AMS) score were compared between different groups.Results No significant differences were found in serum TT, cFT, E2, SHBG, FSH, LH levels and CN -AMS scores between the ligation group and the control group ( P >0.05 ) .No significant differences were found in all indicators between the 10 years group, the 20 years group and the control group(P>0.05).The cFT levels of the 30 years group were significantly lower than the control group (P<0.05), the other indicators had no significant difference(P>0.05).Conclusion The vasectomy has no long-term effect on gonadal function in middle-aged and elderly men.