CAJ | 학술논문

人羊膜上皮细胞（human amniotic epithelial cells，hAECs）是从胎盘内膜内壁分离纯化的一种可表达干细胞表面标记物的细胞。受精后第8天hAECs开始形成，这些细胞具有干细胞多向分化潜能。 hAECs具有促进小鼠脑内神经递质水平增加、减少炎症反应、分泌神经营养因子等营养、支持神经元存活的作用。应用实验动物模型研究对阿尔兹海默病、帕金森氏病、脊髓损伤、脑卒中等疾病都具有治疗效果。本文根据近年发表的研究报告，总结hAECs移植对中枢神经系统疾病的治疗作用，以探讨hAECs移植对中枢神经损伤保护机制的理论基础。
인양막상피세포（human amniotic epithelial cells，hAECs）시종태반내막내벽분리순화적일충가표체간세포표면표기물적세포。수정후제8천hAECs개시형성，저사세포구유간세포다향분화잠능。 hAECs구유촉진소서뇌내신경체질수평증가、감소염증반응、분비신경영양인자등영양、지지신경원존활적작용。응용실험동물모형연구대아이자해묵병、파금삼씨병、척수손상、뇌졸중등질병도구유치료효과。본문근거근년발표적연구보고，총결hAECs이식대중추신경계통질병적치료작용，이탐토hAECs이식대중추신경손상보호궤제적이론기출。
Human amniotic epithelial cells ( HAECs) are isolated and extracted from placenta inner membrane and express embryonic stem cell surface markers.The HAECs are formed at 8th day from the epiblast after fertilization and possess multiple differentiation potentials.HAECs have the potential differentiation ability into all three germ layers: endoderm, mesoderm, and ectoderm.HAECs promote therapeutic and preventive effects and especially play an important role in treatment of central nervous system diseases.These stem cells inhibit inflammatory reaction and release neurotrophic factors to support the function of neurons.HACEs also exhibit alleviative effect on animal models of Alzheimer’s disease (AD), Parkinson’s disease (PD), spinal cord injury (SCI), stroke, etc.The present review summarizes the recent advances of therapeutic approaches of hAECs on central nervous system diseases and explores their protective mechanisms.