CAJ | 학술논문

目的：研究实验性糖尿病周围神经病变（ DPN）大鼠模型的实时步态行为变化。方法采用一次性腹腔注射45 mg／kg链脲佐菌素建立实验性糖尿病周围神经病变大鼠模型，于注射STZ后12周时进行实时步态行为分析检测。结果注射STZ后12周，与正常组比较，DPN模型大鼠出现了步行周期、速度、足迹平均压强、平衡性和协调性的变化。平均步行周期和四足步行周期显著延长（P＜0.01），速度和四足瞬时速度显著降低（P＜0.01），足迹平均压强增加（P＜0.05），绝对值平均体转角显著增加（P＜0.01），同源协调性和同侧协调性显著降低（P＜0.05）。结论实验性糖尿病周围神经病变大鼠模型可见明显的步态行为变化，可为临床和基础研究提供借鉴。
목적：연구실험성당뇨병주위신경병변（ DPN）대서모형적실시보태행위변화。방법채용일차성복강주사45 mg／kg련뇨좌균소건립실험성당뇨병주위신경병변대서모형，우주사STZ후12주시진행실시보태행위분석검측。결과주사STZ후12주，여정상조비교，DPN모형대서출현료보행주기、속도、족적평균압강、평형성화협조성적변화。평균보행주기화사족보행주기현저연장（P＜0.01），속도화사족순시속도현저강저（P＜0.01），족적평균압강증가（P＜0.05），절대치평균체전각현저증가（P＜0.01），동원협조성화동측협조성현저강저（P＜0.05）。결론실험성당뇨병주위신경병변대서모형가견명현적보태행위변화，가위림상화기출연구제공차감。
Objective To study the real-time gait behavioral changes in rat models of experimental diabetic peripheral neuropathy.Methods Twenty-five SPF Sprague-Dawley rats were randomly divided into experimental group ( 6 males and 7 females) and control group (6 males and 6 females).Diabetes was induced in rats by intraperitoneal injection of streptozotocin ( STZ ) in a dose of 45 mg/kg.The gait behavior in all rats was tested at 12 weeks after diabetes modelling.Results Compared with the control group, the rats with diabetic peripheral neuropathy showed statistically significant different walk cycle extension, walk speed, average print intensity, balance and coordination.The abnormal gait behavior of the rat models was mainly reflected in the increased average and each foot walk cycle extension ( P<0.01 ) , average intensity (P<0.05), absolute average body rotation (P<0.01),and shortened both homologous coupling and homolateral coupling( P <0.05 ) .Conclusions Experimental rat models of diabetic peripheral neuropathy can exhibit obvious changes of gait behavior, and may provide a reference for related clinical and basic research.