CAJ | 학술논문

目的：探讨泪腺腺样囊性癌S-100蛋白及神经细丝酸性蛋白（ glial fibrillary acidic protein， GFAP）的表达及其意义。方法收集手术切除泪腺腺样囊性癌28例标本，根据临床症状及组织学观察分为嗜神经侵袭组（15例）和无嗜神经侵袭组（13例），并取术中切除的正常泪腺组织9例为正常对照。应用免疫组织化学SP染色法检测S-100及GFAP在上述组织中表达的差异。结果嗜神经侵袭性生长组的S-100、GFAP阳性表达分别为12例（80％）和9例（60％），与无嗜神经侵袭性生长组S-100阳性5例（41．67％）、GFAP阳性表达率为0相比，呈显著升高趋势，差异有统计学意义（P＜0．05）。结论 GFAP、S-100在有嗜神经性侵袭的腺样囊性癌中有特异性表达，其侵袭特性可能与肿瘤细胞中存在着神经膜细胞分化有关。
목적：탐토루선선양낭성암S-100단백급신경세사산성단백（ glial fibrillary acidic protein， GFAP）적표체급기의의。방법수집수술절제루선선양낭성암28례표본，근거림상증상급조직학관찰분위기신경침습조（15례）화무기신경침습조（13례），병취술중절제적정상루선조직9례위정상대조。응용면역조직화학SP염색법검측S-100급GFAP재상술조직중표체적차이。결과기신경침습성생장조적S-100、GFAP양성표체분별위12례（80％）화9례（60％），여무기신경침습성생장조S-100양성5례（41．67％）、GFAP양성표체솔위0상비，정현저승고추세，차이유통계학의의（P＜0．05）。결론 GFAP、S-100재유기신경성침습적선양낭성암중유특이성표체，기침습특성가능여종류세포중존재착신경막세포분화유관。
Objective To investigate the expression of Schwann's cell markers S-100 and GFAP in lacrimal adenoid cystic car-cinoma, and to explore the relationship between GFAP or S-100 expression and neural invasion of adenoid cystic carcinoma. Methods Twenty-eight lacrimal adenoid cystic carcinoma and 9 normal lacrimal gland specimens were collected .Each specimen was stained by S-P( streptavidin/peroxidase) immuno-histochemical staining.The expression of S-100 and GFAP was analyzed by immuno-histochemistry in order to find the difference in the above-mentioned tissues.One-way ANOVA, Student,s test, chi-square test or line-ar correlation were carried out for statistical evaluation.Results The average S-100 Index(S-100LI) in nor-neural invasion group and neural invasion group were 0.62 ±1.19 and 16.73 ±24.74,respectively,in lacrimal gland adenoid cystic carcinoma.(P<0.05). The average GFAP LI in nor-neural invasion group and neural invasion group were 0 and 2.07 ±3.01,respectively,in lacrimal gland adenoid cystic carcinoma.(P<0.05).Conclusions Schwann’s cell markers GFAP and S-100 in neural invasion group is higher than that in nor-neural invasion group (P<0.05).The Schwann’s cell differentiation may account histologically for the neural inva-sion of lacrimal gland adenoid cystic carcinoma.