CAJ | 학술논문

目的：探讨肺癌患者介入治疗前后血浆纤维蛋白原(FIB)和血浆 D-二聚体(D-D)变化的临床意义。方法23例肺癌患者，同时收集27例正常对照组，比较肺癌患者 FIB 与正常对照人群有何不同，入组肺癌患者均行常规支气管动脉灌注化疗术。所有患者均于首次介入治疗前及第3次介入治疗前分别测定血浆 FIB 和 D-D 值。结果肺癌组血浆 FIB 含量介入术前明显高于正常对照组及介入术后组，而介入术后组与正常对照组无明显差异；肺癌组介入术前后血浆 D-D 含量变化有明显差异。结论肺癌患者介入治疗前后血浆 FIB 和 D-D 含量的变化与肺癌患者病情的严重程度及介入治疗疗效显著相关，可作为介入治疗疗效评估的指标。
목적：탐토폐암환자개입치료전후혈장섬유단백원(FIB)화혈장 D-이취체(D-D)변화적림상의의。방법23례폐암환자，동시수집27례정상대조조，비교폐암환자 FIB 여정상대조인군유하불동，입조폐암환자균행상규지기관동맥관주화료술。소유환자균우수차개입치료전급제3차개입치료전분별측정혈장 FIB 화 D-D 치。결과폐암조혈장 FIB 함량개입술전명현고우정상대조조급개입술후조，이개입술후조여정상대조조무명현차이；폐암조개입술전후혈장 D-D 함량변화유명현차이。결론폐암환자개입치료전후혈장 FIB 화 D-D 함량적변화여폐암환자병정적엄중정도급개입치료료효현저상관，가작위개입치료료효평고적지표。
Objective To explore the clinical significance of plasma fibrinogen(FIB)and plasma D-dimer (D-D)changes involved in lung cancer patients before and after interventional therapy.Methods 23 patients with lung cancer,27 cases of normal control group collected at the same time,to compared the difference of plasma FIB between patients with lung cancer and the normal control group.All enrolled patients were treated with bronchial artery infusion chemotherapy.Plasma FIB and D-D of all patients were meas-ured before the first and the third interventional therapy.Results Plasma FIB value of patients before interventional therapy was sig-nificantly higher than that of the normal control group and the group after interventional therapy.The difference between the group after interventional therapy and the normal control group was no significant;Plasma D-D value of patients before and after interven-tional therapy was significant.Conclusion Changes of plasma FIB and D-D before and after interventional therapy in patients with lung cancer are significantly correlated with the severity of the disease and interventional therapy efficacy,which can be used as a ver-y meaningful indicator of interventional therapy.