CAJ | 학술논문

目的：探讨心肌损伤标志物与脓毒症预后之间的关系。方法收集深圳市福田区人民医院综合 ICU 脓毒症患者44例，将预后分为死亡组及存活组，比较两组患者入院24 h 心肌损伤标志物：肌酸激酶同工酶（CK_MB）、心肌肌钙蛋白 I（cTn I）以及急性生理和慢性健康状况（APACHEⅡ）评分；分别比较两组患者24 h 及48 h 心肌损伤标志物的差异。结果死亡组患者24 h APACHEⅡ、cTn I 显著高于存活组（p ＜0?05）；两组 CK_MB 比较差异无统计学意义；死亡组患者48 h cTn I 显著高于24 h（p ＜0?05），48 h 与24 h 时 CK_MB 水平比较差异无统计学意义；存活组48 h 与24 h 时 CK_MB、cTn I 水平比较差异无统计学意义。结论脓毒症患者 cTn I 越高，预后越差。早期动态检测 cTn I 可作为评价脓毒症患者疾病严重程度及预后一个较可靠的指标。
목적：탐토심기손상표지물여농독증예후지간적관계。방법수집심수시복전구인민의원종합 ICU 농독증환자44례，장예후분위사망조급존활조，비교량조환자입원24 h 심기손상표지물：기산격매동공매（CK_MB）、심기기개단백 I（cTn I）이급급성생리화만성건강상황（APACHEⅡ）평분；분별비교량조환자24 h 급48 h 심기손상표지물적차이。결과사망조환자24 h APACHEⅡ、cTn I 현저고우존활조（p ＜0?05）；량조 CK_MB 비교차이무통계학의의；사망조환자48 h cTn I 현저고우24 h（p ＜0?05），48 h 여24 h 시 CK_MB 수평비교차이무통계학의의；존활조48 h 여24 h 시 CK_MB、cTn I 수평비교차이무통계학의의。결론농독증환자 cTn I 월고，예후월차。조기동태검측 cTn I 가작위평개농독증환자질병엄중정도급예후일개교가고적지표。
Objective To investigate the correlation between markers of myocardial damage and prognosis in sepsis.Methods Forty_four ICU patients with sepsis were divided into survival group and death group. The two group’s markers of my_ocardial damage:CK_MB cTn I and APACHEⅡ score of 24 hours after admission were compared. And the differences of 24 h and 48 h markers of myocardial damage between the two groups were compared. Results In death group,24 h APACHE II, cTn I were higher than that in the survival group(p < 0. 05). CK_MB had no significant difference between the two groups. In death group,48 h cTn I was higher than that of 24 h(p < 0. 05),the difference of CK_MB between the 48 h and 24 h had no significant difference. In the survival group,CK_MB and cTn I had no significant differences between 48 h and 24 h.Conclusion For patients with sepsis,the higher CTn I,the worse the prognosis. Early dynamic detection of cTn I can be as a reliable indicator to evaluate the severity and prognosis in patients with sepsis.