临床医学
臨床醫學
림상의학
CLINICAL MEDICINE
2014年
12期
35-36
,共2页
酮咯酸氨丁三醇%酒石酸布托啡诺%骨折%疼痛
酮咯痠氨丁三醇%酒石痠佈託啡諾%骨摺%疼痛
동각산안정삼순%주석산포탁배낙%골절%동통
Ketorolac tromethamine%Butorphanol tartrate%Fracture%Pain
目的：比较单用酮咯酸氨丁三醇和酮咯酸氨丁三醇联合酒石酸布托啡诺用于治疗骨折术后急性疼痛的效果。方法80例骨折术后急性疼痛患者，拟采用酮咯酸氨丁三醇或酮咯酸氨丁三醇联合酒石酸布托啡诺治疗，随机均分为两组。两组镇痛负荷剂量均为酮咯酸氨丁三醇30 mg。并继以2 ml∕ h 静脉持续泵注酮咯酸氨丁三醇0?5 mg∕ kg（A 组）及酮咯酸氨丁三醇0?25 mg∕ kg 联合酒石酸布托啡诺10 mg（B 组）。采用视觉模拟量表（VAS 法）评分法评价给药前（T1）、给药后10 min、1 h、2 h、4 h、6 h（分别为 T2、T3、T4、T5、T6）时的镇痛效果，并记录胃部不适、干呕或呕吐等不良反应的发生情况。结果与 T1时点相比，两组 T2、T3、T4、T5、T6时点 VAS 评分明显降低（p ＜0?05）。与 T2~ T5时点相比，两组的 VAS 评分在 T6时点升高（p ＜0?05）。T6时点 A 组的 VAS 评分低于 B 组（p ＜0?05）。B 组胃部不适、干呕或呕吐等不良反应发生率明显低于 A 组（p ＜0?05）。结论采用酮咯酸氨丁三醇酮或酮咯酸氨丁三醇联合酒石酸布托啡诺可有效控制骨折术后急性疼痛，其中酮咯酸氨丁三醇联合酒石酸布托啡诺的使用可明显降低相关不良反应发生率，但有效镇痛时间稍短。
目的：比較單用酮咯痠氨丁三醇和酮咯痠氨丁三醇聯閤酒石痠佈託啡諾用于治療骨摺術後急性疼痛的效果。方法80例骨摺術後急性疼痛患者，擬採用酮咯痠氨丁三醇或酮咯痠氨丁三醇聯閤酒石痠佈託啡諾治療，隨機均分為兩組。兩組鎮痛負荷劑量均為酮咯痠氨丁三醇30 mg。併繼以2 ml∕ h 靜脈持續泵註酮咯痠氨丁三醇0?5 mg∕ kg（A 組）及酮咯痠氨丁三醇0?25 mg∕ kg 聯閤酒石痠佈託啡諾10 mg（B 組）。採用視覺模擬量錶（VAS 法）評分法評價給藥前（T1）、給藥後10 min、1 h、2 h、4 h、6 h（分彆為 T2、T3、T4、T5、T6）時的鎮痛效果，併記錄胃部不適、榦嘔或嘔吐等不良反應的髮生情況。結果與 T1時點相比，兩組 T2、T3、T4、T5、T6時點 VAS 評分明顯降低（p ＜0?05）。與 T2~ T5時點相比，兩組的 VAS 評分在 T6時點升高（p ＜0?05）。T6時點 A 組的 VAS 評分低于 B 組（p ＜0?05）。B 組胃部不適、榦嘔或嘔吐等不良反應髮生率明顯低于 A 組（p ＜0?05）。結論採用酮咯痠氨丁三醇酮或酮咯痠氨丁三醇聯閤酒石痠佈託啡諾可有效控製骨摺術後急性疼痛，其中酮咯痠氨丁三醇聯閤酒石痠佈託啡諾的使用可明顯降低相關不良反應髮生率，但有效鎮痛時間稍短。
목적：비교단용동각산안정삼순화동각산안정삼순연합주석산포탁배낙용우치료골절술후급성동통적효과。방법80례골절술후급성동통환자，의채용동각산안정삼순혹동각산안정삼순연합주석산포탁배낙치료，수궤균분위량조。량조진통부하제량균위동각산안정삼순30 mg。병계이2 ml∕ h 정맥지속빙주동각산안정삼순0?5 mg∕ kg（A 조）급동각산안정삼순0?25 mg∕ kg 연합주석산포탁배낙10 mg（B 조）。채용시각모의량표（VAS 법）평분법평개급약전（T1）、급약후10 min、1 h、2 h、4 h、6 h（분별위 T2、T3、T4、T5、T6）시적진통효과，병기록위부불괄、간구혹구토등불량반응적발생정황。결과여 T1시점상비，량조 T2、T3、T4、T5、T6시점 VAS 평분명현강저（p ＜0?05）。여 T2~ T5시점상비，량조적 VAS 평분재 T6시점승고（p ＜0?05）。T6시점 A 조적 VAS 평분저우 B 조（p ＜0?05）。B 조위부불괄、간구혹구토등불량반응발생솔명현저우 A 조（p ＜0?05）。결론채용동각산안정삼순동혹동각산안정삼순연합주석산포탁배낙가유효공제골절술후급성동통，기중동각산안정삼순연합주석산포탁배낙적사용가명현강저상관불량반응발생솔，단유효진통시간초단。
Objective To compare the effects of the single use of ketorolac tromethamine and combined usage of ketorolac tromethamine and butorphanol tartrate on acute postoperative fracture pain. Methods Eighty patients with acute postoperative fracture pain subjected to the treatment of single use of ketorolac tromethamine or combination usage of ketorolac tromethamine with butorphanol tartrate were randomly and evenly divided into two groups. Loading analgesic dose in the two groups was 30 mg of ketorolac tromethamine. Ketorolac tromethamine 0. 5 mg∕ kg in group A and ketorolac tromethamine 0. 25 mg∕ kg combined with butorphanol tartrate 10 mg in group B were then continuously pumped with the rate of 2 ml∕ h. Visual analogue scale(VAS)was used to evaluate the analgesic effects before administration(T1)as well as 10 min,1 h,2 h,4 h,and 6 h after administration (T2,T3,T4,T5,T6)respectively. The adverse reactions were also recorded. Results When compared with that at T1,VAS score at T2,T3,T4,T5,and T6 in the two groups both decreased significantly(p < 0. 05). VAS score at T6 was higher than that at T2 _ T5(p < 0. 05)in both groups. VAS score at T6,but not at T1 _ T5,in group A was lower than that in group B (p < 0. 05). When compared with group A,there were less patients with stomach discomfort,vomit or nausea in group B(p <0. 05). Conclusion Single use of ketorolac tromethamine and ketorolac tromethamine combined with butorphanol tartrate have good effect on acute postoperative fracture pain. Furthermore,the latter can reduce the incidence of stomach discomfort,vomit or nausea,as well as the effective analgesic period.
