CAJ | 학술논문

目的：探讨糖尿病周围神经损害（DPN）的特点以及相关危险因素。方法选择2011年8月至2013年8月糖尿病周围神经病变患者100例，根据神经传导速度将患者分为 DPN 组和无 DPN 组，比较两组神经功能及相关因素。结果病程、年龄是 DPN 发生的危险因素，收缩压、空腹血糖、总胆固醇、三酰甘油与 DPN 呈正相关，但差异无统计学意义（p ＞0?05）。细有髓鞘神经纤维、粗有髓鞘神经纤维病变组高密度脂蛋白胆固醇水平下降（p ＜0?05），而且下肢细有髓鞘神经纤维是 DPN 的好发部位。结论糖尿病患者随着年龄的增加、病程时间的增长，DPN 危险系数将不断增加，高密度脂蛋白胆固醇与 DPN 发生发展密切相关。
목적：탐토당뇨병주위신경손해（DPN）적특점이급상관위험인소。방법선택2011년8월지2013년8월당뇨병주위신경병변환자100례，근거신경전도속도장환자분위 DPN 조화무 DPN 조，비교량조신경공능급상관인소。결과병정、년령시 DPN 발생적위험인소，수축압、공복혈당、총담고순、삼선감유여 DPN 정정상관，단차이무통계학의의（p ＞0?05）。세유수초신경섬유、조유수초신경섬유병변조고밀도지단백담고순수평하강（p ＜0?05），이차하지세유수초신경섬유시 DPN 적호발부위。결론당뇨병환자수착년령적증가、병정시간적증장，DPN 위험계수장불단증가，고밀도지단백담고순여 DPN 발생발전밀절상관。
Objective To investigate the characteristics of peripheral nerve damage in diabetes and related risk factors.Methods From August 2011 to August 2013,100 cases of diabetes peripheral neuropathy were selected according to the nerve conduction velocity,the patients were divided into DPN group and non DPN group. The nerve functions and correlation factor were compared between the two groups. Results The course of disease,age were risk factors of DPN,SBP,FPG,total choles_terol(TG),triglyceride( TC)was positively correlated with DPN,but the difference was not statistically significant( p >0. 05). HDL_C levels fine myelinated nerve fiber and coarse myelin ted nerve fibers damage group were decreased(p < 0. 05), and lower extremity fine myelinated nervefibers are sites of DPN. Conclusion Patients with diabetes increases with age,dura_tion of growth,DPN will increase the risk coefficient,HDL_C is closely related with the occurrence and development of DPN.