催化学报
催化學報
최화학보
CHINESE JOURNAL OF CATALYSIS
2015年
1期
78-85
,共8页
郭腾龙%姜权彬%余立坤%余正坤
郭騰龍%薑權彬%餘立坤%餘正坤
곽등룡%강권빈%여립곤%여정곤
β-氯代烷基芳基酮%Heck反应%烯酮%Domino反应%查尔酮
β-氯代烷基芳基酮%Heck反應%烯酮%Domino反應%查爾酮
β-록대완기방기동%Heck반응%희동%Domino반응%사이동
β-Chloroalkyl aryl ketone%Heck reaction%Enone%Domino reaction%Chalcone
通过Domino脱HCl/Pd(OAc)2催化的Heck反应实现了β-氯代烷基芳基酮、酯和酰胺与卤代芳烃的交叉偶联反应,高效合成了查尔酮类化合物。利用原位生成烯酮为中间体进行反应的策略,减少副反应的发生,从而提高反应的效率。该方法对各种官能团的容忍性好,为从氯代烷烃出发直接合成查尔酮类化合物提供了一条新途径。
通過Domino脫HCl/Pd(OAc)2催化的Heck反應實現瞭β-氯代烷基芳基酮、酯和酰胺與滷代芳烴的交扠偶聯反應,高效閤成瞭查爾酮類化閤物。利用原位生成烯酮為中間體進行反應的策略,減少副反應的髮生,從而提高反應的效率。該方法對各種官能糰的容忍性好,為從氯代烷烴齣髮直接閤成查爾酮類化閤物提供瞭一條新途徑。
통과Domino탈HCl/Pd(OAc)2최화적Heck반응실현료β-록대완기방기동、지화선알여서대방경적교차우련반응,고효합성료사이동류화합물。이용원위생성희동위중간체진행반응적책략,감소부반응적발생,종이제고반응적효솔。해방법대각충관능단적용인성호,위종록대완경출발직접합성사이동류화합물제공료일조신도경。
A new method has been developed for the cross‐coupling of aryl halides with β‐chloroalkyl aryl ketones and their ester and amide analogs through a domino dehydrochlorination/Pd(OAc)2‐cata‐lyzed Heck reaction sequence. The enone intermediates generated in situ reduced the occurrence of side reactions and therefore enhanced the efficiency of the reaction. This reaction exhibited good tolerance to various functional groups on both substrates and provides rapid access to a wide range of chalcone derivatives.