CAJ | 학술논문

目的：探讨胃癌患者胃癌多层螺旋CT灌注成像及灌注参数与肿瘤因子的相关性。方法随机选择我院肿瘤科2010年1月至2012年9月收治的32例胃癌患者作为观察组、体检中心随机选取的健康研究对象40例作为对照组，对两组研究对象均采用CT灌注成像检测，比较两组研究对象的CT灌注成像经灌注软件包处理后的血流量(Perfusion)(即单位时间内每100g肾组织内通过的血液量)、血容量(即100g肾组织内的血液容量(BV))，峰值强化(PEI)，达峰时间(TTP)，平均通过时间(MTT)，表面通透性(PS)及相关肿瘤因子水平差异，并采用Pearson相关分析法分析CT灌注参数与肿瘤因子的相关性。结果观察组和对照组Perfusion、PEI、TTP、PS比较差异具有统计学意义(p<0.05)；两组间BV、MTT比较差异不具有统计学意义(p>0.05)；观察组的肿瘤因子CEA、AFP、CA199、CA72-4水平均显著的高于对照组且差异具有统计学意义(p<0.05)；Perfusion、PEI、PS与肿瘤因子CEA、AFP、CA199、CA72-4呈显著的正相关性， TTP与肿瘤因子CEA、AFP、CA199、CA72-4呈显著的负相关性。结论通过对胃癌患者胃癌进行多层螺旋CT灌注成像检测，可以有效分析肿瘤因子的水平，两者间存在良好的相关性。
목적：탐토위암환자위암다층라선CT관주성상급관주삼수여종류인자적상관성。방법수궤선택아원종류과2010년1월지2012년9월수치적32례위암환자작위관찰조、체검중심수궤선취적건강연구대상40례작위대조조，대량조연구대상균채용CT관주성상검측，비교량조연구대상적CT관주성상경관주연건포처리후적혈류량(Perfusion)(즉단위시간내매100g신조직내통과적혈액량)、혈용량(즉100g신조직내적혈액용량(BV))，봉치강화(PEI)，체봉시간(TTP)，평균통과시간(MTT)，표면통투성(PS)급상관종류인자수평차이，병채용Pearson상관분석법분석CT관주삼수여종류인자적상관성。결과관찰조화대조조Perfusion、PEI、TTP、PS비교차이구유통계학의의(p<0.05)；량조간BV、MTT비교차이불구유통계학의의(p>0.05)；관찰조적종류인자CEA、AFP、CA199、CA72-4수평균현저적고우대조조차차이구유통계학의의(p<0.05)；Perfusion、PEI、PS여종류인자CEA、AFP、CA199、CA72-4정현저적정상관성， TTP여종류인자CEA、AFP、CA199、CA72-4정현저적부상관성。결론통과대위암환자위암진행다층라선CT관주성상검측，가이유효분석종류인자적수평，량자간존재량호적상관성。
Objective To explore the correlation between gastric cancer multi-slice spiral CT perfusion imaging and perfusion and tumor factor. Methods 32 cases of gastric cancer patients random selected from Department of oncology in our hospital from 2010 January to 2012 September as the observation group, 40 cases healthy subjects randomly chosen in the physical examination center as control group, the two groups of subjects were using CT perfusion imaging, compared blood flow perfusion software into the packet processing after the CT perfusion (Perfusion)(blood volume or per unit time per 100gin renal tissue)、blood volume (100g in renal tissue of blood within the capacity of (BV))、peak enhancement (PEI), time to peak (TTP),mean transit time (MTT), permeability surface (PS) differences and related tumor factor levels of two groups, and analyzed the correlation between CT perfusion parameters and tumor factor by using Pearson analysis method. Results The observation group and the control group Perfusion, PEI, TTP, PS with significant difference (p<0.05) between the two groups; BV, MTT difference was not statistically significant (p>0.05); observation group tumor factor CEA, AFP, CA199, CA72-4 levels were significantly higher than those in the control group and the difference was statistically significant (p<0.05);Perfusion, PEI, PS and tumor factor CEA, AFP,CA199, CA72-4 there is a significant positive correlation between TTP and tumor factor, CEA, AFP, CA199, CA72-4 showed a significant negative correlation between. Conclusion Multi-slice spiral CT perfusion imaging in detection of gastric cancer can effectively analyze tumor factor level, there is a good correlation between them.